Lecture 6 inhibitors and allostery

Question 1

what is the catalytic effficiency of an enzyme

Answer 1

kcat/KM

Question 2

Konstanten k kaldes

Answer 2

hastighedskonstanten

Question 3

eksempel på en nulte ordens reaktion

Answer 3

alkohol-nedbrydning i leveren uafhængig af alkohol-mængden i blodet

Question 4

omsætning af ethanol og methanol i leveren?

Answer 4

alkohol dehydrogenase oxiderer ethanol til acetaldehyde.

methanol til formaldehyde

Question 5

hvilket enzym bliver brugt til nedbrydning af kokain

Answer 5

carboxylesterase

Question 6

where does the biggest part of cocain breakdown take place?

Answer 6

In the liver but it does happen elsewhere and it’s catalysed by enzymes or happens without enzymes

Question 7

metabolism of alcohol and cocain

Answer 7

the first one is independent of alcohol present in blood

the latter is dependent on the intake pattern

Question 8

Types of bisubstrate reactions and the difference?

Answer 8

Sequential
alle substrates bound before products released
ping pong
products released before all substrates bound

Question 9

slope of lineweaver-burk plot is

Answer 9

KM/Vmax

Question 10

In which type of bisubstrate reactions, no ternary complex is formed?

Answer 10

ping pong

Question 11

typer af reversible hæmmere

Answer 11

1- kompeititive
2- unkompetitive
3-blandede kompetitive

Question 12

kompetitive hæmmere og naturlige substrater har den samme ….
hvad med unkompetitive
og blandede non-kompetitive

Answer 12

Vmax

Question 13

What does Cyanide, H2S, CO and azide (N3-) do in the body

Answer 13

competitively inhibits cytochrome C oxidase

complete shutdown of ATP-synthesis

Question 14

What does CO do in the body

Answer 14

affects both cytochrome c oxidase and hemoglobin

Question 15

allosteric enzymes can have

Answer 15

multiple subunits and they constitute cooperative binding