Lecture 6: Health Maintenance Flashcards
What qualifies as postmenopause?
No menstrual flow for 12+ months
What is metrorrhagia?
Menstrual bleeding between cycles
aka intermenstrual bleeding
What is considered polymenorrhea?
20 days or less
What is menometrorrhagia?
Completely irregular bleeding
metrorrhagia is between cycles
What is considered oligomenorrhea?
35 days or more
poly is 20
What time period qualifies as amenorrhea?
No menstrual period in over 6 months
What is cryptomenorrhea and what is it AKA
unusually light menstrual flow or spotting only
“hypomenorrhea”
What might contact bleeding suggest?
Cervical cancer
Postcoital, contact cervical
What does a radical hysterectomy remove?
what about a subtotal hysterectomy?
- Uterus
- Cervix
- Pericervical tissue
- Upper vagina
subtotal = uterine corpus only (not cervix)
what is removed during the following propcedures:
1. oophorectomy
2. Salpingectomy
3. salpingo-oophorectomy
- one or both ovaries
- one or both oviducts
- one or both ovaries and oviducts
What is a BSO?
Bilateral salpingo-oophorectomy
Removal of ovaries and tubes
TAH and TVH
- TAH: total abdominal hysterectomy
- TVH: total vaginal hysterectomy
what is the timing of preterm infants vs abortion considered
preterm - 20-36 wks
abortion - <20 wks
what is the difference between a spontaneous, therapeutic and elective abortion
- spontaneous - due to natural causes
- therapeutic - induced for medical reasons
- elective - induced for non-medical reasons
what is stillborn
birth of an infant who has died in the womb typically after 20 weeks gestation:(
what is:
grand multigravida
grand multipara
great grand multipara
- grand multigravida: a woman who has been pregnant 5+ times
- grand multipara - a woman who has delivered 5+ infants 24+ weeks gestation
- great grand muulti para - same but 7+ infants delivered
When does the first reproductive health visit tend to occur?
13-15
start of puberty?
What occurs at the first reproductive health visit?
- Health info
- If symptomatic: pelvic or STD screen may be needed
When do we start pap smears and pelvic exams?
- Pap smears: 21 unless symptomatic, even if active
- Pelvic exams: 21, but depends on s/s and hx.
do you need a pelvic exam prior to starting birth control
NO
How often are pap smears?
Every 3-5 yrs
Usually start at age 21.
When are CBE indicated?
- controversial
- if done, do every 1-3 yrs for 20-39 y/o
- yearly CBE and mammogram for 40+ y/o
- does NOT replace mammogram
no longer routinely recommended if no s/s
Ideal setup for a well woman exam
- Cloth gowns
- Calming + aesthetic environment
- One breast at a time (cover the other)
- Allow companion if no issues
Although SBE is no longer recommended, what should a woman keep in mind if she still intends to examine her breasts?
- Visual exam for changes/dimpling
- Palpate all quadrants
- Examine same time every month
What test needs to be done prior to the bimanual exam?
Pap smear
PANCE-wise, what do you lubricate the speculum with?
Warm water
Describe a traditional pap smear
- Cervical scraping around external os via SPATULA
- BRUSH in endocervical canal. 360deg rotation. apply on same slide as step one.
brOOm Outside, brush inside
for newer method: use ThinPrep test
What structures are palpated during a bimanual exam? what are normal findings?
- Cervix - 3/4 cm in diameter and moderately firm/mobile w/o discomfort
- Uterus - half size of pts fist. smooth, regular outline, nontender, mobile.
- Adnexa: fallopian tubes and ovaries - usually only palpable in sim women. not in overwieght/postmenopausal women!
describe a rectovaginal examination
which finger goes where, what are you palpating?
- insert well-lubricated middle finger of examining hand into rectum.
- insert index finger of examining hand into vagina
- raise cervix towards anterior abdominal wall and palpate uterosacral ligaments
According to ACS guidelines, when are comprehensive skin exams indicated?
- For 20-40, Q3y
- For 40+, Q1y
encourage UV ray SPF 30 or higher
Pap smear frequencies
- 21-29: every 3 years
- 30-65: every 3 years OR HPV +/- pap every 5
- 65+: can stop if no hx of dysplasia/cx + 3 negative paps or 2 negative paps/HPVs in past 10y
- Guidelines do not apply to cervical cx, HIV+, immuno, or DES exposure
What STDs should all pregnant women be screened for regardless of risky behavior?
- Hep B
- HIV
- Syphilis
HHS
What age should pregnant women be screened for gonorrhea/chlamydia?
< 25y
or anyone w high risk sexual behavior. also Hep c if high risk.
For non-pregnant women, what are the STD screenings?
- HIV once if low risk
- Gonorrhea/Chlamydia annually if < 25
- If high risk: HIV/syph/trich/hepB/C/Gonorrhea/Chlamydia/(+/- HSV)
what is considered high risk sexual behavior
non-intuitive ones (in my head at least):
* young age
* African american race
* unmarried
* living in low Socioeconomic area
* new partner in last 60 days
Intuitive ones (in my head):
* illicit drug use
* admission to correctional facility
* multiple sexual partners
* hx of prior STI
* contact w sex workers
* meeting partners on internet.
Generally, when do you start mammograms?
- ACS/ACOG/ACR: annually at 40-45 (can change to biennial esp at age 55)
- USPSTF/WHO/ACP/AAFP: Biennial starting at 50
USPSTF -“insufficient evidence to continue past age 74”
many providers do it as long as woman is in good health and expects to live 10+ more years
When do you stop mammograms?
- Life expectancy < 10y and in poor health
- After age 74 on average
Generally, when do you start colonoscopy screening?
45
USPSTF - no screening after 75
When is DEXA scan recommended?
- women 65+
- woman < 65 but you have the fx risk of a 65+ white female with no other RFs
- No recommendations for men
You do it about every 2 years, no set frequency
What does a 65y white woman with no other RFs have for their osteoporotic risk?
9.3% 10 year risk
FRAX?
How are pap smears graded?
Bethesda system
What are the two types of atypical squamous cells in the besthesda system?
- ASC-US (undetermined significance)
- ASC-H (cannot exclude high-grade lesion)
What does LGSIL/LSIL (low-grade squamous intraepithelial lesion) correspond to? (CIN ranking)
CIN-I
CIN = cervical dysplasia (gogle says Cervical intraepithelial neoplasia)
CIN 1 = lower 1/3 of epithelial lining of cervix
CIN 2 = lower 2/3^^
CIN 3 = over 2/3 ^^
What does high-grade squamous intraepithelial lesion (HGLSIL/HSIL) correspond to? (CIN ranking)
CIN-II or CIN-III
What are atypical grandular cells/AGC associated with?
Adenocarcinoma of the endocervix or endometrium
Describe CIN 1/2/3
- CIN-I = disordered growth of lower 1/3
- CIN-II = disordered growth of lower 2/3
- CIN-III = disordered growth of over 2/3; considered full thickness
When do you always treat CIN?
CIN-2/3 always treated unless pregnant or CIN 2 in adolescents.
adolescent = high chance of spontaneous regression and lower risk of cancer
Top 2 highest risk HPV strains
- HPV 16: 50-70% of all cervical cancers
- HPV-18: 7-20% of all cervical cancers
HPV is in 80% of all CIN lesions + 99.7% of all invasive cervical cx.
BUT most HPV + women do not develop CIN or cervical cancer
What is the major estrogen prior to menopause? After?
- Estradiol/E2 is the major secretory product of the ovaries, and is far more MC than estrone/E1
- After menopause: estrone/E1 is MC as long as you’re not on hormone replacement.
EstrONE = 1st, estraDIol = 2
What secondary risk factor tends to synergistically increase risk of cervical cancer?
HPV with SMOKING
What is the major estrogen during pregnancy?
Estriol/E3
prEgnancy
Tx for ASC-US
- Repeat cytology q6m until 2 normal.
- Test for high-risk HPV (16/18)
- Colposcopy
Any option viable. Colposcopy if top 2 are abnormal.
Make sure to tx hormones and infections prior to repeating smears.
When are estrone levels ordered?
- Monitoring antiestrogen therapy
- Adjunct assessment in fx risk
- Disorders of sex steroid metabolism
- Delayed/precocious puberty
typically only doninant in menopause
Next step in management for LSIL/HSIL/ASC-H/AGC
Colposcopy
When is estriol ordered?
- Quad screen in 2nd trimester
- Screening for fetal pathologies
- Marker for fetal demise
- Assess preterm labor risk
primary estrogen in pregnancy
When is estradiol ordered?
- Monitoring antiestrogen therapy
- Disorders of sex steroid metabolism
- Evalulating ovarian function
- Monitoring HRT
- Elevated in hepatic cirrhosis or hyperthyroidism
primary estrogen prior to menopause
what is a colposcopy
illuminated low-power magnification to inspect cervix, vagina, vulva, and anal epithelium
What is done in colposcopy?
- Biopsies
- Endocervical samples via curette or brushing
Addition of acetic acid makes lesions turn white
no endocervical sampling done if pt is preggo
Where can progesterone be secreted by?
- Corpus luteum (post ovulation)
- Adrenal glands (conversion to other steroids, no contribution unless tumor)
- Placenta (primary by end of 1st trimester)
Indications for colposcopy (5)
- Abnormal cervical cytology/HPV testing
- Clinically abnormal cervix
- Unexplained metrorrhagia or contact bleeding
- Vulvar/vaginal neoplasia
- History of in utero DES exposure
What can interfere with progesterone readings? (2)
- Adrenal tumors
- Biotin > 5mg/dl
Management of CIN-1 after colposcopy
- 2 pap Q 6 months OR pap + HPV test at 6mo.
- if cytology abnormal or HPV + then repeat colposcopy.
- if 2 cytology smears normal and/or HPV neg then routine screening resumes
monitor because HIGH chance of spontaneous REGRESSION
When are FSH/LH low?
- Pituitary failure
- Hypothalamic failure
- Pregnancy
- Anorexia/malnutrition
- OCPs
Management of CIN 2/3 & invasive cx or abnormal findings after colposcopy
Surgery
When are FSH/LH high?
- Menopause
- Castration
- Precocious puberty (age-adjusted)
FSH/LH are high when estrogen and progesterone are low.
Summary of pap smear/biopsy results and followup
Currettage for AGC and HSIL
Main inihibitor of prolactin
Dopamine
What drug classes can boost prolactin?
- Antipsychotics
- Antiemetics
- Antidepressants
- THC
- Ergots
- Opiates
- Methyldopa
- Verapamil
Meds tend to cause a 2-4x ULN rise.
Mainly psych meds
S/S of hyperprolactinemia
- Men: impotence
- Women: oligomenorrhea/amenorrhea
- MSK: decreased muscle mass and osteoporosis
Pap smear result and treatment chart for abnormal findings/abbreviations