Lecture 6: Choroid Flashcards
the choroid is what layer of the eye?
The vascular layer of the eye (tunica vasculosa)
what color is the choroid and why?
Dark brownish color due to melanocytes
what is the choroid composed of?
blood vessels, melanocytes, and connective tissues
the choroid is firmly attached to what 3 locations?
- Scleral spur
- Exit of vortex veins
- Optic nerve
The Vascular layer is composed of three structures; what are they?
- iris (anteriorly)
- ciliary body
- choroid (posteriorly)
what three structures form a continuous tract?
- iris (anteriorly)
- ciliary body
- choroid (posteriorly)
the choroid is the posterior aspect of what?
- posterior aspect of the uveal tract
what does the choroid contain?
Contains blood vessels, melanocytes, connective tissue, & mucinous extracellular fluid
what is the primary function of the choroid?
Nourishes outer layers of the retina
what is the secondary function of the choroid?
Serves as a heat exchange
what structure accounts for 85% of the blood flowing through the eye?
choroid
list the choroid layers from inner to outer.
- Bruch’s membrane
- Choriocapillaris
(Capillary layer) - Choroidal Stroma
(Vessel layer) - Suprachoroid lamina
where is the choroid located?
Located between sclera and retina
where does the choroid extend?
Extending from ora Serrata to optic nerve
where is the thickest and thinnest part of the choroid?
Thickest 0.2mm at the posterior pole
Thinnest 0.1mm at ora Serrata
Suprachoroid lamina has a potential space between what?
Potential space between the sclera and choroidal vessels
what does the Suprachoroid lamina contain?
Contains collagen bands, fibroblast and melanocytes
what causes the Suprachoroid lamina to detach?
Can swell without causing detachment
what does the Suprachoroid lamina carry?
Carry LPCA and LPCN from posterior to anterior
Choroidal stroma
Pigmented vascularized, loose CT layer
what does the Choroidal stroma contain?
containing melanocytes,
fibroblasts, macrophages, lymphocytes, and mast cells
(Choroidal stroma) Haller’s layer:
outer with large lumina vessels
(Choroidal stroma) Sattler’s layer:
medium-sized vessels
what do the venules in the Choroidal stroma join to become?
The venules join to become four large vortex veins
Clinical relevance: Choroidal stroma
Clinical relevance: high density of melanin granules àpotential for choroidal melanoma
(can not miss in the clinic!!!)
Choriocapillaris:
Specialized capillary bed, a single layer of anastomosed, fenestrated
capillaries with wide lumina
where are Choriocapillaris densest?
macula
what is a unique structure to the choroid and what does it provide?
pericytes (provide local blood flow regulation)
Bruch’s membrane: what layer of the choroid is it?
The innermost layer of the choroid fuses with the retina
Allow nutrients inflow to the retina and remove waste products
what are the five layers of Bruch’s membrane?
- BM of RPE
- Inner collagenous zone
- Elastic layer
- Outer collagenous zone
- BM of Choriocapillaris
T/F: Bruch’s membrane acellular
T
what does Bruch’s membrane contain elements of
elements of the choroid and RPE
what does Bruch’s membrane surround?
it surrounds the optic disc and extends peripherally to the ora serrata
where is Bruch’s membrane the thickest and the thinnest
- Thickest near the optic disc (2-4 microns)
* Thinner peripherally (1-2 microns)
what is the posterior choroid supplied by?
10- 20 SHORT POSTERIOR CILIARY ARTERIES (SPCA)
what is the anterior choroid supplied by?
2 LONG POSTERIOR CILIARY ARTERIES (LPCA) and Anterior Ciliary arteries (ACA)
where does the anterior and posterior systems meet?
The two systems meet at the equator and are connected with each other via recurrent vessels
Drusen:
deposit of waste material from the retina
characteristics of AMD
where is Drusen found?
Between the inner collagenous layer of Bruch’s and BM of RPE
Angoid streaks:
damage to the elastic layer of bruch’s
**Psuedoxanthoma elasticum, ehlersdanlos syndrome, pagets disease, sickle cell disease, and Idiopathic (PEPSI)
Choroidal neovascular membranes (CNVM) results from what?
a break in bruch’s membrane
what casues Choroidal neovascular membranes (CNVM)?
Due to pathological myopia, Exudative ARMD, Histoplasmosis, Choroidal rupture