Lecture 6-8 Flashcards
Muscle makes up what percentage of mass in humans?
30-50%
What types of muscle are striated? Non-striated?
Striated: skeletal and cardia
Non-striated: smooth
What types of muscles are voluntary and which are involuntary?
Voluntary: skeletal
Involuntary: Cardiac and smooth
Look at skeletal histology
FREAKING DO IT BECAUSE IT IS TOO DAMN STUPID TO TYPE OUT
What is the protein associated with thick filaments in sarcomeres?
Myosin
What does the head of the thick filaments do?
They bind actin and have ATPase activity
What is tropomyosin?
Double stranded helix that covers the myosin binding site on actin
-regulatory and keeps actin from constantly binding to myosin
What does troponin T do?
It binds the troponin complex to tropomyosin
What does troponin I do?
It holds tropomyosin in the myosin binding site
-inhibitory function
What does troponin C do?
Binds calcium
-uncovers the myosin binding site
What does Dystrophin do?
Connects sarcomere to sarcolemma and extracellular matrix
Mutations with dystrophin cause what?
The most common form of muscular dystrophy
what is nebulin?
structural protein that holds thin filaments apart from eachother
what is alpha actinin?
structural protein that holds thin filaments to Z-disc
what is titan?
spring that runs through heavy chain and connects it to the z-disc
