Lecture 6 Flashcards
What are 5 volatile anesthetics?
- Halothane
- Enflurane
- Isoflurane
- Desflurane
- Sevoflurane
What are gaseous anesthetics?
-Nitrous oxide
What are three desirable qualities of inhaled anesthetics?
- Rapid induction (onset)
- Rapid termination (elimination)
- Effect compartment
What are four factors that control uptake of nitrous oxide?
- Inspire concentration
- Ventilation
- Solubility
- Cardiac output
How is solubility measured?
-Partition coefficient
An increase in cardiac output does what with nitrous oxide?
-Increases its uptake in the blood
What is the Partial pressure of O2 in the alveolus?
-103 mmHg
What is the partial pressure of O2 in capillaries?
-40 mmHg
T/F Nitrous oxide is relatively insoluble in the blood
True
What is the onset of action of Nitrous oxide for inhalation?
-Less than 20 seconds with 2-3 minutes for clinical actions to develop
How long does it take to reach the peak clinical effect of nitrous oxide for inhalation?
-3-5 minutes
What is the depth of sedation for nitrous oxide for inhalation?
-Sedation levels easily changed either way
What is the duration of action for inhalation of nitrous oxide?
-Duration variable, at discretion of administrator
What is the recovery time for the inhalation of nitrous oxide?
-Recover usually complete following 3-5 minutes of inhalation of 100% O2
What is diffusion hypoxia?
-Hangover effect
How can diffusion hypoxia occur?
-If pt. breathes room air at conclusion of N2O-O2 sedation
How do you prevent diffusion hypoxia?
-Administer 100% O2 for 5 minutes at termination of procedure
Is titration possible with inhalation of nitrous oxide ?
-Yes
What is the ability to titrate nitrous oxide mean?
-Adds safety to administer Nitrous oxide
T/F Nitrous oxide has analgesic properties so it can be used instead of local anesthetic in certain procedures
True
What are the disadvantages of Nitrous oxide?
- Initial cost of equipment
- N2O is not a potent agent, failures can occur
- must be able to inhale gases through nose
What are three indications for nitrous oxide?
- Management of fear and anxiety
- Medically compromised pts
- Management of gagging
When giving nitrous oxide to the medically compromised pts with cardiovascular disease what effects does it have?
- Lower anxiety means lower myocardial ischemia
- Oxygen administration
- Analgesic effect of N2O
When giving nitrous oxide to someone with respiratory disease what should you know?
- Administered safely to asthmatic pts
- N2O is non-irritating to trtacheo-bronchial tree
- Increased stress is potential cause of acute exacerbation of asthma
- May not work with chronic nasal obstruction
- Relative contraindication with COPD
When giving nitrous oxide to someone with Cerebrovascular disease (stroke) what does it do to anxiety and blood pressure?
- Reduce
- It is also good for these pts because you are administering O2 that helps these pts