lecture 6 Flashcards
1
Q
cholinoceptor blocking agents ____ block muscarinic receptors
A
- reversibly
2
Q
atropine lasts
A
- 7-10 days
3
Q
scopolamin lasts
A
- 3-7 days
4
Q
homatropine, cyclopentolate, tropicamide, ipratropium lasts
A
- hours
5
Q
side effects of cholinoceptor blocking agents (muscarinic)
A
- pupil size increases (mydriasis)
- inhibits ciliary function - loss of accommodation
- decrease tear production
- bronchodialation
- dry mouth and gastric motility
- urinary retention
- decreased sweating
- increase heart rate
- psychosis (CNS)
6
Q
clinical uses for cholinoceptor blocking agents
A
- urinary incontinence (darifenacin)
- motion sickness (scopolamine)
- GI hyperactivity (atropine)
- asthma (tropicamine and ipratropium)
7
Q
uses for antinicotinic agents
A
- neuomuscular blocker during surgery
8
Q
botulinum toxin type A is used to treat
A
- muscle spasms, cerebral palsy, ticks, stabismus, nystagmus
9
Q
action of a-1 adrenoceptor
A
- contract vascular smooth muscle
- increase heart rate and force of contraction
10
Q
action of a-2 adrenoceptor
A
- act on pre-synaptic nerve terminals in CNS
11
Q
action of b-1 adrenoceptors
A
- increase heart rate, contraction force
12
Q
action of b-2 adrenoceptors
A
- relaxation of respiratory and vascular smooth muscle
13
Q
with adrenergic agoinist you worry about ____ effects
A
- systemic
14
Q
indirect-acting amines (adreno activating) act by
A
-induce the release of NE from nerve terminals
