lecture 5 Flashcards
sympathetic origin
- thoracolumbar
parasympathetic origin
- cranio-sacral
all preganglionic neurons use _____ as NT
- ACh
all postganglionic parasympathetic neurons use _____ as NT
- ACh
sympathetic post-ganglionic used _____ as NT
- NE
all preganglionic receptors are _____
- nicotinic
all postganglionic parasympathetic receptors are
- muscarinic
postganglionic sympathetic receptors are
- adrenergic
somatic nervous system acts on
- muscles
sympathetic action on eyes
- pupil enlargement, mydriasis
- contraction of radial muscle
sympathetic action on lungs
- relax bronchioles smooth m.
parasympathetic action on lungs
- constricts bronchiole smooth m.
sympathetic bladder action
- relaxes bladder
parasympathetic bladder action
- contracts bladder
two types of autonomic receptors
- cholinergic and adrenergic
recycling cholinergic ACh
- acetylcholinesterase (AChE)
recycling adrenergic
- reuptake by presynaptic neuron
- monoamine oxiidase (MAO)
- catechol-o-methyl transferase (COMT)
nicotinic receptors
- alters ion channels
muscarinic receptors
- alters metabolism
effects of cholinergic agents
- binds to Ah receptor and activates
- increases parasympathetic activity
- increases GI activity, sweat, tear production, salivary secretions, miosis of eye, constriction of bronchiols, decrease in heart rate and strength of contractions
indirect acting cholinergic agoinists
- inhibit AChE
- prolonge ACh in synapse
toxicities of cholinergic agonists (parasympathetic storm)
- diarrhea, urination, miosis, bradycardia, bronchoconstriction, excitation, lacrimation, salivation
