lecture 4 Flashcards
1
Q
the study of the effect of the body on a given drug
A
- pharmacokinetics
2
Q
the concentration is measured in the _____ of the blood
A
- plasma
3
Q
the concentration of first order elimination is plotted as
A
- log of serum concentration vs. time
4
Q
first order kinetics
A
- a constant fraction of the drug is removed per unit time
5
Q
zero order kinetics
A
- a constant amount of drug is removed per unit time, regardless of the concentration of the drug
6
Q
an example of a zero order drug
A
- ethanol
7
Q
alpha phase of elimination
A
- distribution
8
Q
beta phase of elimination
A
- elimination
9
Q
the time it takes for the concentration in plasma to decrease by half
A
- pharmokinetic half-life
10
Q
relationship between elimination constant and half life
A
- 0.693 = Ke * T1/2
11
Q
value which enables to predict how much drug must be given to obtain a specific plasma concentration of drug
A
- volume of distribution
12
Q
volume of distribution
A
- plasma conc (at time=0) = amount given/apparent volume of distribution
13
Q
volume of fluid which is cleared of the drug in unit time
A
- clearance
14
Q
clearance
A
- Cl = Ke(Vd)
15
Q
It take _____ for a drug to be 99% removed
A
- 5-6 half lives
