Lecture 5 - staging in kidney disease Flashcards
acute kidney injury is followed by accumulation of:
what does this lead to?
toxins
fluids
electrolytes
acids
this leads to metabolic acidosis!
what are 3 ways of measuring GFR?
- Crt clearance
- Iohexol clearance
- nuclear scintigraphy
what is initial AKI staging based on?
Crt levels
these are fluid stages; they will change from day to day
what is our target BP with chronic kidney disease?
> 65mmHg in order to perfuse the kidneys
what is the definition of CKD?
kidney damage for > 3 months defined by functional abnormalities with or without decrease in GFR caused by pathological abnormalities.
when do we see a change in Crt? is it sensitive?
not until 60 - 65% of the kidneys are gone. NO!
with mild renal insufficiency, kidneys are still ______ functional.
40 - 90%
what are clinical signs of mild renal insufficiency?
PU/PD
anorexia
vomiting
CS of moderate renal insufficiency?
azotemia anorexia weight loss anemia metabolic acidosis hyperparathyroidism
CS of severe renal insufficiency/failure?
severe azotemia anorexia vomiting weight loss hypertension anemia metabolic acidosis hyperparathyroidism hyperP
what is the relationship of nephrons between cats and dogs
cats have fewer nephrons but they run deeper so they can reabsorb more water
IRIS CKD staging
stage 1, 2, 3, and 4: non-azotemic, mild, moderate and severe
IRIS AKI staging
1, 2, 3-4-5: non-azotemic, mild azotemia and all moderate-severe azotemic
acute kidney injury is a disturbance of:
hemodynamics
filtration
tubulo-interstitial
outflow injury
