Lecture 5: Physiology of the Visual System Flashcards

1
Q

What is Refraction?

A

Fact or phenomenon of light, radio waves, etc., being deflected in passing obliquely through the interface between one medium and another or through a medium of varying density

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2
Q

What part of the eye is the first involved in refraction of light and what other structure in the eye also plays a role; which is fixed and which is variable?

A
  • The cornea is the first site of refraction (is fixed) = 2/3’s of light bending
  • The lens adds variable amount of bending, depending on the curvature of the lens
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3
Q

How does a round vs. flat lens affect the refraction of light?

A

Round = more refraction

Flatter = less refraction

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4
Q

What is involved in increasing the curvature of the lens of eye and what kind of vision is this useful for?

A
  • Ciliary muscle contracts, which allows suspensory ligaments to loosen
  • Lens assumes a more rounded shape by natural recoil
  • Used for near vision
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5
Q

What is involved in decreasing the curvature of the lens of eye and what kind of vision is this useful for?

A
  • Ciliary muscle relaxes, which causes the suspensory ligaments to tighten
  • The lens is pulled tight, flattening it.
  • Used for far vision
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6
Q

When an object is far away, what happens to the light rays entering our eyes and how does this play a role in adjusting our vision?

A
  • Light rays have diverged far enough that only parallel light rays enter the eye
  • They don’t need to be bent a lot to focus on retina, so the lens is best off flat
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7
Q

When an object is nearby, what happens to the light rays entering our eyes and how does this play a role in adjusting our vision?

A
  • Light rays are still diverging and need a lot of bending to focus on the retina
  • Requires our body to increase the curvature of the lens to compensate
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8
Q

What is the purpose of the increased curvature of the lens of the eye and what occurs with age?

A
  • Allows light rays from a nearby object to be bent sufficiently to bring them into focus on the retina
  • With age, the lens stiffens and loses elasticity = presbyopia = near vision becomes more difficult
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9
Q

Near visions requires 2 additional changes on top of contraction of the ciliary muscle, what are they?

A

1) Convergence of the the eyes to the point of focus
2) Constriction of the pupil

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10
Q

How does constriction of the pupil contribute to near vision?

A
  • Reduce the opening for light to enter
  • Eliminates some of the diverging light rays, so we don’t need to bend as many to focus on the retina
  • Allows us to focus better
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11
Q

Which 3 cells are in the vertical pathway of the retina and what is this pathway used for?

A

1) Photoreceptor
2) Bipolar cell
3) Ganglion cell
- This is the pathway for relaying the visual info to the brain

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12
Q

Glutamate release within the retina is highest when?

A
  • HIGHEST in the dark
  • No stimulation by photons
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13
Q

Glutamate release within the retina is lowest when and why?

A
  • LOWEST when there is light
  • Stimulation by photons causes the cells to hyperpolarize
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14
Q

What are the 3 steps in the activation of the bipolar cells by cone photoreceptors?

A
  1. Photon stimulates photoreceptor
  2. Photoreceptor hyperpolarizes
  3. Glutamate release onto the bipolar cell DECREASES
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15
Q

What are ON-center bipolar cells, how are they activated, and what increases their discharge rate?

A
  • Activation of a photoreceptor in the center of this bipolar cell’s receptive field causes depolarization of this bipolar cell
  • Activation in the periphery of this bipolar cell’s receptive field causes hyperpolarization of this bipolar cell
  • These cell increase their discharge rate to luminance increments in the receptive field center
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16
Q

What are the OFF-center bipolar cells, how are they activated, and what increases their discharge rate?

A
  • Activation of a photoreceptor in the center of this bipolar cell’s receptive field causes hyperpolarization of this bipolar cell
  • Activation in the periphery of this bipolar cell’s receptive field causes depolarization of this bipolar cell
  • These cell increase their discharge rate to luminance decrements in the receptive field center
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17
Q

What is the glutamate receptor in depolarizing bipolar cells and what is its function?

A
  • A metabotropic receptor (Gi, GPCR) that is activated by glutamate
  • Closes cGMP-gated ion channels similar to light transduction in photoreceptors = hyperpolarizes cell
  • Channels open when less glutamate is present
18
Q

Explain the process of activation of an ON-center bipolar cell by cone photoreceptors in light conditions.

A
  • Photons decrease the presence of glutamate
  • Less glutamate = less activation of Gi-GPCR metabotropic receptor on the ON-center bipolar cell
  • Less Gi signaling
  • Results in an increase in cation influx into the bipolar cells = DEPOLARIZATION
19
Q

What type of glutamate receptor found on OFF-center bipolar cells and what is the effect of light and dark on them?

A
  • An AMPA receptor is activated and glutamate causes an INCREASE in cation influx (Na+ and some Ca2+)
  • In the dark, the OFF-center cell is depolarized since glutamate release is high
  • With light, glutamate release from the photorecptor decreases and AMPA receptor is NOT activated = OFF-center cell hyperpolarized
20
Q

Explain the activation that occurs to the OFF-center bipolar cells when light hits cone photoreceptors?

A
  • Light decreases the presence of glutamate
  • Less glutamate = less activation of AMPA receptor on the OFF-center bipolar cell
  • Results in decrease in cation influx into the bipolar cell
  • Hyperpolarizes the cell
21
Q

Explain the activation that occurs to the ON-center bipolar cells in the dark by cone photoreceptors?

A
  • Glutamate is high and activates the Gi GPCR-metabotropic receptor on the ON-center bipolar cell
  • Results in a decrease in cation influx into the bipolar cell
  • Hyperpolarizes the cell
22
Q

Explain the activation that occurs to OFF-center bipolar cells by cone photoreceptors in the dark?

A
  • Increased glutamate would activate AMPA receptor on the OFF-center bipolar cell
  • Results in an increase in cation influx into the bipolar cell (Na+ and Ca2+)
  • Depolarizes the cell
23
Q

How are ganglion cells linked to bipolar cells, how are they activated, rely on what NT?

A
  • Ganglion cells are also ON-center and OFF-center varieties (whichever kind of bipolar cell its connected to)
  • When bipolar cell is activated, releases glutamate to depolarize the ganglion cell
  • Depolarization —> threshold —> AP
24
Q

Ganglion cell axons become ______

A

the fibers of the optic nerve

25
Q

How is a bipolar cell activated by rod photorecptors?

A
  • Many rods converge on one ON-center Bipolar cell
  • Which then synapses on an A11-amacrine cell and rod-bipolar cell
  • Which then synapses on a Cone ON-Center bipolar cell
  • Then activates a Ganglion cell
26
Q

Why do we require many rods to coverge on a bipolar cell?

A
  • Rods do vision in low light situation
  • Many rods converging on a bipolar cells increases our chanches of seeing what we need to see
27
Q

What is the specific function of ON-center and OFF-center cells in refining the signal to the retina (i.e., tells us what)?

A
  • The ON-center cell tells us where something is
  • The OFF-center cell tell us where it ends
28
Q

What is the function of amacrine cells and horizontal cells in refining the signal in the retina?

A

Work by providing inhibitory (GABA/glycine) modulation that modifies the activity of neighboring photoreceptors, bipolar cells, or ganglion cells

29
Q

Where is the AP related to vision and activation of the retina actually occuring?

A

Ganglion cells - axons of these cells become fibers of optic nerves

30
Q

Light from the right visual field hits what part of each retina?

A
  • The left temporal retina of left eye
  • The right nasal retina of right eye
31
Q

What are the 4 main functions of the LGN?

A

1) Control the motion of the eyes to converge on point of interest
2) Control the focus of the eyes based on distance
3) Determining relative position of objects to map them in space
4) Detect movement relative to an object

32
Q

The primary visual cortex has how many layers and what is each responsible for?

A

- Six layers

  • Layers 1, 2 and 3 allow networking betweem V1 and other parts of cortex
  • Layer 4 receives inputs from the LGN
  • Layers 5 and 6 send information BACK to LGN
33
Q

What is the Ocular dominance of columns in primary visual cortex?

A
  • Columns span all 6 layers of the cortex
  • A slab of cells that preferentially respond to input from one eye or the other (ocular dominance)
  • Each column does a different job and neighboring columns have related jobs
34
Q

What is the major job of the primary visual cortex (V1)?

A

Identify the edges/contours of the objects in our visual image

35
Q

What is the major job of the primary visual cortex V2?

A
  • Identify disparities in the visual images presented by two eyes
  • These disparities are used for DEPTH PERCEPTION
36
Q

What is the function of neurons knows as ‘blobs’ found within the columns of the visual cortex?

A
  • Organized region of neurons that are sensitive to color
  • ALL 3 color-coding cones are required for accurate color detection
37
Q

What is the major job of the primary visual cortex area V3A?

A

Identification of motion

38
Q

What is the major job of the primary visual cortex area V4?

A

To complete the processing of color inputs

39
Q

What is the Dorsal pathway for the processing of visual inputs and where does it arise from?

A
  • From V3 of the primary visual cortex and goes to the parietal/frontal cortex
  • Enables us to complete motor acts based on visual input
40
Q

What is the Ventral pathway for the processing of visual inputs and where does it arise from?

A
  • From primary visual cortex to the inferior temporal cortex, allowing for the integration of visual input with other sensory inputs to accomplish higher order functions
  • Primarily involved in interpreting images (recognizing or copying shapes, forms, faces) and complex patterns
41
Q

The ventral pathway relays visual information to areas of brain involved in higher processing of sensory inputs such as what; why does damage to this area not always lead to a complete loss of function?

A
  • Copying/namingobjects areseparate functions in the temporal lobe.
  • Damage to one area is possible WITHOUT damaging the others
  • Facial recognition is a specialized area