Lecture 2: Motor Reflexes Flashcards

1
Q

What are the 2 Cortically mediated reflexes?

A

1) Placing reaction: baby automatically trying to step on something when being held and feet slightly brush up against a surface
2) Hopping reaction: being pushed and hopping to maintain balance

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2
Q

What are the 5 brainstem/midbrain mediated reflexes?

A

1) Vestibular
2) Righting reflex
3) Suckle (children)
4) Yawn
5) Eye/head movements

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3
Q

What are the 3 spinally mediated reflexes?

A

1) Stretch (myotatic) and (deep-tendon reflex)
2) Golgi tendon reflex
3) Crossed extensor

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4
Q

How do reflexes compare to volitional motion; what are the major differences?

A
  • In order for relfexes to be effective, must be very precise and this precision makes reflexes look like volitional movement
  • BUT reflex movements occur FASTER than even the fastest voluntary movement
  • Reflexes mediated at all levels of CNS, voluntary motion originates in cortical areas
  • Reflexes elicited even when unconscious, voluntary motion requires conscious awareness
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5
Q

What is the appearance, purpose, and characteristics (i.e., initiated by and what type of reflex) of the Myotatic (stretch) reflex?

A

Appearance: contraction (shortening) of a stretched muscle

Purpose: protect muscle from tearing due to over-stretch

Characteristics: initiated by muscle spindle.

  • Monosynaptic, segmental reflex
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6
Q

α-motor neurons innervate which muscle fibers, resulting in?

A

Innervate extrafusal muscle fibers (the fibers resulting in contraction)

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7
Q

γ-motor neurons innervate which muscle fibers, which are a component of what?

A
  • Innervate the intrafusal muscle fibers, a component of the muscle spindle
  • Intrafusal fibers are distributed in parallel arrangement w/ the extrafusal fibers of skeletal muscle
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8
Q

What are the components of a muscle spindle?

A

A motor component and a sensory component

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9
Q

What are the characteristics of the sensory portion of the muscle spindle, sensitive to what, and what does it contain?

A
  • Is NOT contractile
  • Is the portion sensitive to length
  • Is acutally TWO sensors - with different afferents
    1) Nuclear bag fiber
    2) Nuclear chain fiber
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10
Q

What fiber is the primary afferent of the muscle spindle, innervates what, and is sensitive to?

A
  • The Ia fiber (LARGE and myelinated)
  • Innervates both the nuclear bag and nuclear chain
  • Sensitive to both: length of muscle AND how fast length is changing
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11
Q

What fiber is the secondary afferent of the muscle spindle, innervates what, and is sensitive to?

A
  • The smaller, myelinated Group II fiber
  • Innervates only the nuclear chain fiber
  • Sensitive only to the length of the muscle
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12
Q

What innervates the motor portion (intrafusal contractile elements) of a muscle spindle and what is the function of this portion?

A
  • γ-motoneuron
  • By contracting the intrafusal portion, we stretch the sensory portion and it becomes even more sensitive to a superimposed stretch

- Controls the sensitivity

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13
Q

How does the activity of the γ-motoneuron correlate with sensitivity of the muscle spindle?

A
  • More active γ-motoneuron = more sensitive muscle spindle
  • Less active γ-motoneuron = less sensitive muscle spindle
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14
Q

What does the afferent portion of the muscle spindle do within the spinal cord and this leads to what?

A
  • Forms an excitatory synapse directly on the homonymous muscle’s alpha motor neuron in the ventral horn of the SC
  • This is a monosynaptic connection
  • Also forms an excitatory synapse on GABAergic inhibitory interneurons that inhibit the antagonist muscle (forms the basis of reciprocal innervation)
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15
Q

How does the end result of the activity of alpha vs. gamma motor neurons differ?

A

Alpha = directly leads to motion

Gamma = causes contraction, but does NOT directly lead to motion

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16
Q

What is reciprocal inhibition and how is it involved in the myotatic (stretch) reflex; why is it important?

A
  • The Ia afferent enters the SC, synapses and releases EAA’s on the alpha-motor neuron, BUT..
  • The Ia afferent also gives off a branch which synapses on an interneuron which will inhibit the alpha-motor neuron of the antagonist muscle
  • Allows the antagonist muscle to relax and lengthen
17
Q

The muscle spindle can be stretched by what 2 mechanisms?

A

1) Stretch of the whole muscle
2) By stimulation of the gamma motor neurons that produce contraction of the ends of the muscle spindle

18
Q

What are the 5 sequences of events involved in the stretch reflex (i.e., the spindle, afferents, and excitation)?

A
  1. Muscle stretch, either by manipulation or by tendon tap
  2. Muscle spindle stretch (due to the in-parallel arrangement)
  3. Increase discharge of spindle Ia afferents
  4. Excitation of α-motoneurons
  5. Muscle contraction increases to oppose the stretch
19
Q

What is the Golgi Tendon reflex also referred to?

A

Inverse myotatic w/ autogenic inhibition

20
Q

What is the appearance of the Golgi Tendon reflex, the purpose, and what initiates it/type of reflex?

A
  • Sudden (abrupt) relaxation of a contracted muscle
  • Protect muscle from damage due to excessive force
  • Initiated by golgi tendon organ
  • Polysynaptic, segmental reflex
21
Q

The Golgi Tendon organs innervate what and what type of fiber do they utilize?

A
  • Innervate tendon
  • Bare nerve ending with lots of branches; Ib fiber to spinal cord
22
Q

What happnes to the AP’s in golgi tendon organs as tension increases?

A

AP’s increase w/ tension

23
Q

What is the order of events (5 of them) for the Golgi tendon reflex?

A

1) Muscle contracts putting massive strain on tendon
2) Increased tension increases AP’s in Ib afferent fiber
3) Ib afferent synapses on inhibitory interneuron in SC
4) Inhibition of the α-motorneuron of the same muscle
5) Muscle abruptly relaxes and tension on tendon is relieved

24
Q

What is the NT released by the inhibitory interneuron in the Golgi Tendon reflex?

A

Glycine

25
Q

What type of synaptic reflex is a Myotatic (stretch) vs. Golgi tendon (reverse myotatic)?

A

Myotatic (stretch) is a monosynaptic reflex; contraction of a stretched muscle back to normal length

Golgi tendon is a polysynaptic reflex; abrupt relaxation of contracted muscle (protective)

26
Q

What is Spinal shock; how long does it last; what helps with recovery?

A
  • An acute spinal cord injury w/ loss of reflexes and sensation below the level of the transection
  • All reflexes abolished even if circuit is intact
  • Gradual recovery in humans: week-years; partly due to loss of excitatory bias from CNS
  • Some of the recovery seems to be due to sprouting of axons below the transection to form synapses on neighboring cells
27
Q

What is Spasticity vs. Rigidity; which motor neurons contribute to each?

A

Spasticity: is an increased resistance to the passive movement of a joint in a given direction; from continual activation of gamma-motor neurons

Rigidity: increased resistance in all directions; from continual activation of alpha-motor neurons

28
Q

Decerebrate posturing is a result of; what is seen with the pathology?

A
  • Loss of all structures/input rostral to the pons; extensive UMNL
  • Contraction of all anti-gravity muscle (arms in extension, head is arched back)
  • Rigidity due to an increase in α-motoneuron excitability
  • Spasticity due to an increase in γ-motorneuron firing
29
Q

Which reflex is hyperactive in Spasticity and this condition is usually associated with what type of lesion?

A
  • Myotatic reflex (stretch) is hyperactive
  • Hear spasticity, think UMN lesion
30
Q

What is seen with the upper limbs, lower limbs, and head position with decorticate posturing?

A
  • Flexion of the upper limb joints
  • Extension of the lower limbs
  • Dependent on head position!
31
Q

The brainstem inhibitory regions requires activation from what regions and what is its actions on gamma-motor neurons; how is the region related to spasticity/decerebrate posturing?

A
  • Requires activation from cortical regions and inhbits gamma-motor neurons
  • Makes muscle spindle less sensitive
  • An injury producing decerebrate posturing abolishes activity of cortex so activation of gamma-motor neurons is unopposed
32
Q

Why are clinicians extremely likely to see patients with unilateral decorticate posturing?

A
  • Is a result of strokes in the vicinity of the internal capsule
  • A relatively common sign for a stroke
33
Q

How does head position affect the positon of someone with Decorticate posturing?

A
  • If head neutral, affected leg extended and affected arm somewhat flexed
  • If you rotate the head either direction - increases extensor tonus of arm on side head is rotated towards but flexion of the opposite arms
34
Q

Golgi tendon organs are connected to what type of afferent fiber?

A

Ib afferent fiber