Lecture 5 Part 4: Chlamydia Flashcards
How many species of Chlamydia are associated with human disease?
3
What disease is caused by Chlamydia trachomatis?
Chlamydia trachomatis causes genital infections and conjunctivitis
What disease is caused by Chlamydophila psittaci?
Chlamydophila psittaci causes zoonotic pneumonia
What disease is caused by Chlamydophila pneumonia?
Chlamydophila pneumonia causes atypical pneumonia
slide 36 has a chart look at reservors and transmission
What was Chlamydia originally thought to be?
It was originally thought to be viruses
Are Chlamydia bacteria intracellular or extracellular pathogens?
Chlamydia are intracellular pathogens
What is the structural difference between Chlamydia and typical Gram-negative bacteria?
Chlamydia has a structure similar to Gram-negative bacteria but lacks peptidoglycan
Does Chlamydia contain DNA and RNA?
Yes, Chlamydia contains both DNA and RNA
What type of ribosomes does Chlamydia have?
Chlamydia has prokaryotic ribosomes
list the 4 general properties for chlamydia ?
- Structure similar to Gram(-) bacteria but no peptidoglycan
- Contain DNA and RNA
- Prokaryotic ribosomes
- Synthesize proteins, nucleic acids & lipids
What is unique about Chlamydia’s developmental cycle?
Chlamydia has a unique developmental cycle with two forms
EBs (elementary bodies)
RBs (reticulate bodies)
What are EBs (elementary bodies) in Chlamydia?
EBs are inactive, infectious forms of Chlamydia
What are RBs (reticulate bodies) in Chlamydia?
RBs are active, noninfectious forms of Chlamydia
What types of cells does Chlamydia trachomatis infect?
Limited range of cells to infect
it infects Non-ciliated columnar, cuboidal & transitional epithelia
What are the species-specific outer membrane proteins of Chlamydia trachomatis?
The outer membrane proteins are MOMP (major outer membrane protein) and OMP2 (outer membrane protein)
What is the role of Chlamydia trachomatis’s outer membrane proteins?
These proteins help prevent the formation of the phagolysosome
How is Chlamydia trachomatis transmitted?
It is transmitted by person-to-person contact through sexual activity, respiratory droplets, or from mother to child during birth
What is the leading cause of preventable blindness?
Chlamydia trachomatis is the leading cause of preventable blindness
What is the most common sexually transmitted disease in the United States?
Chlamydia trachomatis is the most common sexually transmitted disease in the U.S
How does Chlamydia trachomatis cause persistent infections?
It causes persistent, often asymptomatic infections
What is trachoma, and how does it affect the eyes?
Trachoma is a chronic disease caused by Chlamydia trachomatis, leading to conjunctivitis, vascularization, corneal scarring, and blindness.
Can Chlamydia trachomatis cause pneumonia?
Yes, Chlamydia trachomatis can cause pneumonia
true or false
Chlamydia trachomatis can cause urogenital infections (as many as 80% of women are asymptomatic)
true
What is Lymphogranuloma venereum (LGV) caused by Chlamydia trachomatis?
.
LGV is characterized by the enlargement of genital lymph nodes and subsequent symptomatic dissemination
