Lecture 4 Part 4: Haemophilus and Bordetella Flashcards
What is the shape and Gram-stain characteristic of Bordetella?
Bordetella is an extremely small, Gram-negative coccobacillus
What type of metabolism does Bordetella exhibit?
Bordetella is a strict aerobe and nonfermentative, oxidizing amino acids
Which Bordetella species causes whooping cough?
Bordetella pertussis causes whooping cough (pertussis)
What illness is caused by Bordetella parapertussis?
Bordetella parapertussis causes a mild pertussis
Which Bordetella species is associated with respiratory disease in animals?
Bordetella bronchiseptica is associated with respiratory disease in animals
What serious condition can Bordetella holmesii cause?
Bordetella holmesii can cause sepsis
Name 3 adhesins produced by Bordetella?
1.pertacitn
2. filamentous hemagglutinin
4. fimbriae
What is the mechanism of action of pertussis toxin?
Pertussis toxin is an A-B toxin.
The A subunit binds to cell surface proteins
The B subunit inactivates G1α, leading to increased cAMP levels and increased secretions
What is the role of adenylate cyclase toxin/hemolysin in Bordetella?
increases cAMP levels
What is the effect of dermonecrotic toxin in Bordetella infections?
dermonecrotic toxin is a heat-labile toxin that causes vasoconstriction
What is the function of tracheal cytotoxin?
it is a peptidoglycan monomer that inhibits cilia and, at high concentrations, causes cell extrusion
What components make up the lipopolysaccharides (LPS) in Bordetella?
Lipid A or lipid X
slide 44 is a table
ask if we need to know it?
