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CVPR 322 Physiologic assesment > Lecture 5 Oxygen > Flashcards

Lecture 5 Oxygen Flashcards

1
Q

Oxygen that diffuses from the lung or oxygenator into blood is carried in two forms

A

(PaO2)

SO2

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2
Q

Oxygen dissolved in plasma ?

Percentage?

A

PaO2

2%

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3
Q

Oxygen bound to hemoglobin ?

Percentage?

A

SO2

98%

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4
Q

Hb consist of____ heme groups, each heme molecule can carry 1 oxygen molecule

A

4

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5
Q

measurement of of the amount of oxygen bound to Hb measured in percent)

A

Oxygen Saturation

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6
Q

Hb + O2 =

A

HbO2

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7
Q

One gram of Hb can carry ?

A

1.36 mL O2

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8
Q

_____ _____ reflects optimal conditions that exist to facilitate oxygen loading ion the lung and unloading in the tissue

A

Sigmoid Shape

oxyhemoglobin dissociation curve

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9
Q

oxyhemoglobin dissociation curve reflects a relationship between ____ ____ ?

A

Y= SO2 (Oxygen Saturation)

X = PO2 (Partial Pressure)

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10
Q

What does “Hemoglobin-oxygen affinity” mean ?

A

strength of bond between Hb and O2

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11
Q

P50

A

PO2 value where 50% of the hemoglobin is saturated

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12
Q

What is a normal P50 value under standard conditions ?

A

27 mmHg

(pH=7.40, PCO2=40mmHg,
37C, normal 2,3 DPG)

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13
Q

Picture the oxyhemoglobin dissociation curve, In arterial blood,
Large ∆s in PO2 result in

A

Small ∆s in SO2

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14
Q

Picture the oxyhemoglobin dissociation curve, In venous blood,
small ∆s in PO2 result in ?

A

large ∆s in SO2

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15
Q

4 things that can affect oxygen affinity ?

A
  • pH
  • Temperature
  • PCO2
  • 2,3 DPG (a byproduct
    of RBC metabolism)
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16
Q

Colder temp effects affinity shifts by ?

A

Increasing Affinity

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17
Q

Warmer temp effects affinity shifts by ?

A

Decreasing Affinity

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18
Q

What are the results of a LEFT shift in Hemoglobin-oxygen affinity ?

A

↑ affinity between O2 & hgb.

↑ pH
↓ PCO2
↓Temp
↓2,3-DPG

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19
Q

What are the results of a RIGHT shift in Hemoglobin-oxygen affinity ?

A

↓ affinity between O2 & hgb.

↓ pH
↑ PCO2
↑Temp
↑2,3-DPG

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20
Q

2,3 DPG

A

(a byproduct of RBC metabolism)

21
Q

Oxygen Saturation

A

ratio of oxygenated Hb: total Hb in 100 ml blood (%)

22
Q

Arterial Blood Oxygen Supply-Loading.

23
Q

Venous Blood Oxygen Supply-Loading

A

65 - 75% (mixed), SvO2

24
Q

(CaO2)

A

(Oxygen Content)

The amount of oxygen in 100 ml of whole blood

25
Normal Range for Oxygen Content (CaO2) ?
Normal Range = 17 - 20 %
26
CaO2 equation ?
(1.36 x Hb x SO2) + (.0031 x PO2)
27
Dissolved O2 is insignificant at normal CaO2 is highly dependent on what ?
[Hb] & Sats
28
O2 bound to Hb
(1.36 x Hb x SO2)
29
O2 dissolved
(.0031 x PO2)
30
Oxygen (Delivery) | DO2
The amount of oxygen being delivered to the tissues. Units (mlO2/min)
31
(DO2) equation ?
C.O. X CaO2 X 10
32
Oxygen Consumption (extraction)
The total amount of oxygen consumed by the body per minute
33
Oxygen Consumption (VO2) Used in conjunction with oxygen transport (DO2) to assess what?
the balance between oxygen supply & demand
34
Oxygen Consumption (extraction) VO2 normal range ?
200 - 290 mlO2
35
Primary Oxygen Consumption /extraction(VO2) equation ?
C.O. X 10 X Hgb X 1.36 X (SaO2 - SvO2)
36
VO2 =
Oxygen Consumption /extraction | Normal range = 200 -290
37
DO2 =
Oxygen Transport/Delivery Normal Range = 900 - 1000 ml/min
38
CaO2 =
Oxygen Content | Normal Range = 17 - 20 %
39
Oxygen consumption is a good index of
oxygen requirements
40
Dynamics of O2 Supply/Demand. If you ↑ C.O. you, ?
↓ O2 Supply | ↑ O2 Demand
41
Dynamics of O2 Supply/Demand. ↑ O2 Extraction is reflected by ?
Larger Arterial / Venous saturation difference.
42
Dynamics of O2 Supply/Demand. What are the 3 compensatory mechanisms ?
1. ) ↑ C.O. 2. ) ↑ Extraction 3. ) Selective Redistribution
43
4 Specific Threats to O2 Balance ?
1. ) ↑ O2 consumption 2. ) ↓ in Hb 3. ) ↓ in SaO2 4. ) ↓ in C.O.
44
Mixed Venous Oxygen Saturations (SvO2) equation ?
O2 delivered - O2 consumed
45
A decrease in SvO2 indicates what ?
that the body has called upon its last line of defense to preserve O2 balance and intervention may be appropriate.
46
Continuous In-Line Blood Monitoring of blood gas parameters improves and simplifies perfusion management. It also improves what ?
Patient Safety
47
Mixed Venous Oxygen Saturations from a PA catheter ?
good mixing of IVC,SVC, and coronary sinus blood
48
What do you do when on CPB: | SvO2 Drops from 80% to 60% over 5 minutes ?
↑ Flow

CVPR 322 Physiologic assesment (11 decks)

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