Lecture 5 Of Biochemical

Question 1

Potency

Answer 1

measure of drug activity expressed in terms of the amount required to produce an effect.

Question 2

EC50

Answer 2

effective concentration at 50% of maximal response

Question 3

Simple system

Answer 3

Law of mass action
Ligand (drug D) is always in excess
Maximal response: all receptors are bound to ligand/drug (D)
Minimal response: no receptors are bound by ligand/drug (D)

Question 4

Receptor occupancy:

Answer 4

fraction of receptors bound by ligand (drug)

Question 5

Q2-a -A
B-d
C-b
D- d
E- bnot sure