Biochem

Question 1

How ace inhibitors work

Question 2

Angiotensin 1 drive by wheat

Answer 2

Liver and kidney

Question 3

Angiotensin 1 drive by wheat

Answer 3

Liver and kidney

Question 4

An example oh enzyme inhibitors

Answer 4

Ace inhibitors

Question 5

Enzyme inhibitors

Answer 5

The drug targets an enzyme
Inhibitors block the action of protein

Question 6

Common proteins that are targeted by drugs acting as inhibitors are:

Answer 6

Enzymes
Ion channels
Transport proteins

Question 7

The most common target of drugs are:

Answer 7

Receptors
Drugs targeting receptors can stimulate or oppose receptor action

Question 8

ACE inhibitors
Statins
Aspirin

Answer 8

ACE inhibitors Cardiovascular
Statins
Aspirin

Question 9

Warfarin
Rivaroxaban
Dabigatran

Answer 9

Anticoagulant/blood thinners

Question 10

Ibuprofen
Paracetamol

Answer 10

Analgesic/pain

Question 11

Amoxicillin

Answer 11

Antibiotics

Question 12

How do enzyme inhibitors work (1)?

Question 13

How to determine Km?

Answer 13

Carry out a series of experiments:
Enzyme concentration constant
Vary substrate concentration [S]
Determine product formation over time: initial velocity V0

Question 14

How to determine V0?

Answer 14

Carry out a series of experiments:
Enzyme concentration constant
Vary substrate concentration [S]
Determine product formation over time: initial velocity V0 (by linear regression)

Question 15

Lectures 2