lecture 5- membrane proteins Flashcards
membrane proteins used for
•transport •intracellular junction- holds membrane together •receptors •cell-cell recognition •attachment to the cytoskeleton and extracellular matrix
2 main functions
•transport of molecules across membranes •transduction of signals across membranes
peripheral/ extrinsic proteins
•on the outside of the cell- dont permeate through •they have H bonds and oletostatic •these are POLAR interactions can be disrupted by adding salt or changing the pH
intergral/ intrinsic Proteins
•interact with the hydrocarbon chain of membrane lipids that san the lipid bilayer. can only be released b agents that compete for these non-polar interactions
glycoproteins
proteins with attached carbohydrate (sugar) group. same sugars occur in both membrane glycoproteins and glycolipids. sugar on the outside of the cell is called sugar coating
glycocalyx
carbohydrates of glycoproteins and glycolipids occurs on the outer surface of plasma membranes which gives it the sugar coating
function of glycoproteins
•cell-cell recognition •cell adhesion •binding specific substrate
membrane proteins
•carbohydrate containing lipid and protein molecules are also important in cell-cell recognition
structure of membranes
•phospholipids suspended in water- bilayer
membrane fluidity
•controlled by fatty aids and cholesterol •the more the unsaturation o fatty acyl chain the more fluid •increasing the amount of cholesterol makes the membrane less fluid
features of membrane
•1:4 or 4:1 lipid to proteins •membrane lipids are hydrophilic or hydrophobic form bilayers and barriers •separates cell content from enviro •recognition and response •cell adhesion