Lecture 5: Key Things To Remember For Quiz

Question 1

How much oxygen is in plasma?

Answer 1

0.003 ml O2/100 ml plasma…VERY SMALL AMT OF O2 IN PLASMA

Question 2

Hemoglobin is a ___

Answer 2

Oxygen carrier protein

Question 3

Each gm of Hb can carry up to ___ ml of O2

Answer 3

1.31 ml of O2 (theoretically up to 1.39 ml/gm)

Question 4

Hemoglobin combines ___ with O2

Answer 4

Reversibly

Question 5

What does shift to the right mean?

Answer 5

Hb will release O2 to the tissues (less affinity for O2)

Question 6

3 causes of shift to the right

Answer 6

• Decreased pH
• Increased DPG
• Increased temperature

Question 7

What does shift to the left mean?

Answer 7

Hb wants to hold onto oxygen tighter (greater affinity for O2)

Question 8

3 causes of shift to the left

Answer 8

• Increased pH
• Decreased DPG
• Decreased temperature

Question 9

At 50% saturation, PaO2 is ___

Answer 9

27 mm Hg

Question 10

At 75% saturation, PaO2 is ___

Answer 10

40 mm Hg

Question 11

At 90% saturation, PaO2 is ___

Answer 11

60 mm Hg

Question 12

Bohr Effect is seen when the curve shifts to the ___

Answer 12

Right

Question 13

What is oxygen saturation?

Answer 13

The ratio of oxygen bound to Hb compared to the total amount that can be bound

Question 14

What is oxygen capacity?

Answer 14

Maximal amount of O2 bound to Hb

Question 15

Very rough rule—PaO2 of 40, 50, 60 for sats _, _, _

Answer 15

70, 80, 90

Question 16

P50 of Hb = PO2 of ___ mm Hg

Answer 16

27

Question 17

Shift to the right =

Answer 17

Release of O2, less affinity

Question 18

Shift to the left =

Answer 18

Hold onto O2, greater affinity

Question 19

What is CaO2?

Answer 19

Oxygen content in the blood (ml/dL)

Question 20

How do you calculate CaO2?

Answer 20

CaO2 = (SO2 x Hb x 1.31) + (PO2 x 0.003)

Question 21

Four types of hypoxia:

Answer 21

• Hypoxic hypoxia
• Stagnant (ischemic) hypoxia
• Anemic hypoxia
• Histotoxic hypoxia

Question 22

Hypoxic hypoxia =

Answer 22

Low PO2–blood can’t take O2 from the lungs

Question 23

Stagnant (ischemic) hypoxia =

Answer 23

Low perfusion to an organ—not getting oxygen from blood

Question 24

Anemic hypoxia =

Answer 24

Low hemoglobin—not enough hemoglobin to carry O2

Question 25

Histotoxic hypoxia =

Answer 25

Cells can’t use O2 effectively d/t poisoning (i.e.: cyanide poisoning)