Lecture 5 - Buccal Drug Delivery Flashcards
What is the buccal cavity?
the mouth (teeth, tongue and salivary glands)
Sublingual mucosa/membrane
this is the floor of the mouth, and fastest oral route for drug into circulatory system as layer is very thin (0.15mm). It is nonkeratinised and polar.
Buccal membrane
the cheek, upper and lower lip. Slower way of buccal drug delivery than via sublingual. It is non-keratinised and polar.
Topical delivery
via tablet retained in mouth (lozenge)
Why is solution not such a good way of buccal drug delivery?
will be swallowed, therefore won’t interact as much as say gel would be able to
Why is Buccal drug delivery good?
Bypasses first pass effect, stomach and brain blood barrier. goes straight into circulation.
Buccal spray
GLYCERYL TRINITRATE used for angina, also contains tetrafluoroethene which is the propellant, and flavourings)
Disadvantages of Buccal drug delivery
must taste nice, risk of dental caries
Where is buccal mucosa?
gum of cheeks
where is the lower/upper labial muscosa
gum between teeth and lips on to and bottom of mouth
adherent gingiva
gum surrounding teeth forming ‘collar’ around them, maxillary on the top, mandibular on bottom
Choline Salicylate
anti-inflammatory analgesic (technically NSAID, but naturally occurring)
Cetalkonium chloride
antiseptic
Cetylpyridinium chloride
antiseptic (quaternary ammonium- allows surface activity)
Lidocaine
anaesthetic
