Lecture 23 - Tabletting 1 (NOT COMPLETE)

Question 1

Why is particle size important?

Answer 1

Drug bioavailability, settling rate, possibility of obtaining homogeneous mixtures, flowability, tolerability of some dosage forms.

Question 2

What particle size distribution is aimed for?

Answer 2

bimodal

Question 3

Vbulk/apparent

Answer 3

volume occupied by a powder including pores (empty gaps between particles)

Question 4

Vtapped

Answer 4

volume occupied by powder after tapping

Question 5

Vtrue

Answer 5

volume occupied by powder excluding volume occupied by pores

Question 6

Apparent volume

Answer 6

apparent vol before settling (bulk volume) (volume of 100g of substance measured in dry cylinder without compacting)

apparent vol, after settling i dont fucking know

Question 7

Bulk desity

Answer 7

mass/Vbulk

Question 8

True density

Answer 8

mass/Vture

Question 9

packing fraction equation

Answer 9

k=bulk density/true density

Question 10

What will always be lager? bulk or true density?

Answer 10

bulk, because its mass-Vbulk (which includes pours) unlike Vtrue