Lecture 5 Flashcards

1
Q

what is the function of the cytoskeleton

A

Maintains cell shape and position of organelles within cells

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2
Q

why is the cytoskeleton a dynamic structure

A

because it can rapidly disassemble and reassemble to change the cell shape while providing stability

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3
Q

what are the three main components of the cytoskeleton

A

microtubules, microfilaments and intermediate filaments

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4
Q

what are microtubules

A

composed of tubulin subunits, may radiate out from an organising centre(centrosome)

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5
Q

what are the functions of microtubules

A

they resist compression- to help maintain cell shape

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6
Q

what is the motility of microtubules

A

flagella-snake-like motion
Cilia-rowing-like motion
if the cell is fixed then cilia move fluid past
ATP motor proteins can move organelles to target specific cells

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7
Q

what are microfilaments

A

a double chain of actin symbols that form linear strands, 3 dimensional networks

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8
Q

what are the functions of microfilaments

A

resist tension, the cortical network under the plasma membrane helps make this region less fluid and maintains cell shape

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9
Q

what do interactions between actin and motor proteins such as myosin allow

A

muscle contraction
support cell movement
amoeboid movement
cytoplasmic streaming in plants

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10
Q

what proteins make up intermediate filaments

A

keratins in hair
lamins in nucleus
neurofilaments in neurons

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11
Q

what are the characteristics of intermediate filaments

A

supercoiled into cables
less dynamic than microtubules and microfilaments
form relatively permanent cellular structures
help maintain cell shape and anchor organelles
may remain after the cell that made them dies

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12
Q

What are the three types of Cell Junctions

A

Tight Junction, Desmosomes, Gap Junction

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13
Q

What is the function of tight junctions

A

Hold neighbouring cells tightly pressed together

prevent movement of fluid across cell layers

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14
Q

what is the function of Desmosomes

A

Anchoring Junction

work as rivets to provide attachment between sheets of cells and are connected into the cell by intermediate filaments

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15
Q

What is the function of Gap Junction

A

A point of cytoplasmic contact between two cells

allows ions and small molecules to pass from cell to cell and intercellular communication

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16
Q

What are the characteristics of Extracellular Matrix ECM

A

composed of the material secreted by cell (occurs by constitutive exocytosis)
Most ECM proteins are glycoproteins

17
Q

what is collagen

A

collagen fibres have great tensile strength, embedded in a proteoglycan complex matrix

18
Q

what are proteoglycans

A

proteins with extensive sugar added-trap water in ECM

water helps pertain tissue shapes

19
Q

what is fibronectin

A

glycoproteins that attach cells to ECM

20
Q

what are integrins

A

connect ECM to the cytoskeleton

Provide a communicative link from ECM to the cell interior