Lecture 5

Question 1

What is the complement system?

Answer 1

system that consists of several plasma proteins that work together to opsonize microbes, to promote the recruitment of phagocytes to the site of infection, and in some cases to directly kill the microbes

Question 2

What are the three activation pathways of the complement system?

Answer 2

classical
alternative
lectin

Question 3

Early step 1 of the complement pathway is formation of _____ complexes that produce C3a and C3b which trigger ____ and ____ microbes

Answer 3

C3 converstase complexes, inflammation and opsonize

Question 4

Early step 2 of the complement pathway is formation of ______ complexes that produce C5a and C5b which perpetrate ______ and initiates the late steps

Answer 4

C5 convertase; inflammation

Question 5

What is the late steps of the complement pathway?

Answer 5

formation of membrane attach complexes which form holes in microbial membranes