Lecture 2

Question 1

All blood cells develop from ________ cells

Answer 1

common pluripotent stem

Question 2

Where do T lymphocytes proliferate, differentiate and complete their maturation?

Answer 2

the thymus

Question 3

Where do B lymphocytes proliferate, differentiate and complete their maturation?

Answer 3

bone marrow

Question 4

Where are Ag specific receptors located?

Answer 4

on the surface of T and B cells

Question 5

What part of the thymus is involved in generation of T regulatory cells?

Answer 5

Hassall’s corpuscle

Question 6

What is a naive cell?

Answer 6

B cell or T cell that have not yet been exposed to Ag

Question 7

What cytokines play an important role in T cell development?

Answer 7

IL-1, IL-2, IL-6 and IL-7

Question 8

What do T helper cells do?

Answer 8

express CD4 and provide help for B cell growth and differentiation

Question 9

What do cytotoxic t lymphocytes do?

Answer 9

express CD8 and recognize and kill virus infected cells

Question 10

Differentiation into B cells occurs within the fetal ____ and then after birth in the ______

Answer 10

liver; bone marrow

Question 11

What cytokines play a role in the development of B cells?

Answer 11

IL-1, IL-6, IL-7

Question 12

Lymphocytes continuously circulate various parts of the body except what?

Answer 12

eye, brain, testicle

Question 13

How do lymphocytes enter secondary lymphoid organs?

Answer 13

via the high endothelium venues (HEV)

Question 14

How do lymphocytes transmigrate?

Answer 14

by diapedesis

Question 15

What make up the white pulp of the spleen?

Answer 15

T cell and B cell zones

Question 16

What is the function of plasma cells?

Answer 16

secrete antibodies

Question 17

In the absence of Ag stimulation, follicles are _____ follicles

Answer 17

primary

Question 18

What is a primary follicle composed of?

Answer 18

small naive B cells or recirculating memory cells

Question 19

With Ag stimulation, B cells proliferate and differentiate converting the primary follicle to a secondary follicle or a _______

Answer 19

germinal center (GC)

Question 20

What do germinal centers contain?

Answer 20

mitotic B cells

Question 21

What are the professional antigen presenting cells (APCs)?

Answer 21

dendritic cells (DC)
tissue macrophages
B cells

Question 22

What do APCs do?

Answer 22

cells that capture, process, display Ags to T lymphocytes and provide signals the stimulate the proliferation and differentiation of the lymphocytes

Question 23

APC only displays to ____ cells

Answer 23

T

Question 24

Only _____ cells can activate naive T cells in the lymph node

Answer 24

dendritic

Question 25

What cells can present Ags only for activated T cells but not naive T cells?

Answer 25

macrophages and B cells

Question 26

Dendritic cells and macrophages are cells of _____ immunity

Answer 26

innate

Question 27

What are the broad categories of dendritic cells?

Answer 27

classical DCs
myeloid (mDCs)
plasmacytoid (pDCs)

Question 28

macs are derived from ______

Answer 28

monocytes

Question 29

How do DCs acquire Ags?

Answer 29

use phagocytosis, receptor mediated endocytosis, and pinocytosis

Question 30

Activated DCs secrete____

Answer 30

cytokines

Question 31

Where do classical DCs reside?

Answer 31

skin, mucosa, and organ parenchyma

Question 32

plasmacytoid DCs are early cellular responders to _____ infection

Answer 32

viral