Lecture 5 Flashcards
What is the Basal Lamina produced by?
Epithelium
What produces the Reticular Lamina?
Connective Tissues
What are the 5 components of Basal Lamina?
- Laminin
- Fibronectin
- Type IV Collagen
- Entactin
- Proteoglycans
What cells produce type IV collagen?
Epithelial cells
What makes up Laminin and does it have binding sites for?
Alpha, Beta, Gamma chain.
Has binding sites for: Integrins, Type IV Collagen, Entactin, and Proteoglycans.
What is Fibronectin and two cells makes it?
It is a Protein made up of 2 polypeptides chain-crosslinked by Disulfide Bonds.
Made by Fibroblasts (cellular form)
Made by Hepatocytes (plasma form)
What 4 things does Fibronectin have binding sites for?
Heparin
Integrins
Collagen
Fibrin
What are the 2 type of Calcium Dependents CAMS
Cadherins and Selectins
What are the 2 type of Calcium Independent CAMS
Integrins-Extracellular matrix molecules
ImmunoGlobulin Superfamily
ID the 3 classes of Classic Cadherins and where are they found?
- E-type is in epithelial (most common)
- N-Type is in Nerve cells
- P-type is in Placenta
What type of Hemophilic dimers do Cadherins makes?
Trans and Cis
What are the 2 type of NON-Classical Cadherins and where are they found?
Desmocollins & Desmogliens
Found in Macula Adherens.
Loss of E-cadherins is associated with what?
Tumor Cells
What are Catenins?
Small proteins that link with Actin on cytoplasmic side
What are Selectins and do they do?
Bind to Carbs on extracellular side
Help Leukocytes move to from blood to tissue
