Lecture 47 - ECF, Effective Circulating Volume

Question 1

% break down of distribution of water in the human body?

Answer 1

TBW = 60 % of body weight (50% in females)

IntraCellular = 40% of body weight (2/3 of TBW)

Extracellular = 20% of body weight (1/3 of TBW)

          Intravascular  = 15% of TBW  
          Interstitial = 5% of TBW

Question 2

what is the major extra cellular cation?

Major intra cellular cation?

Answer 2

Na + – -Total body Na leads to expansion of Interstial Volume = EDEMA

K +

Question 3

Describe conditions which can disrupt starling forces?

Answer 3

Cirrhosis – Low oncotic pressure; therefore decreased intravascular volume, increases interstial volume (Edema)

Nephrotic Syndrome – Proteinuria

Protein Losing Enteropathy -

CHF – increased venous pressures

Burns – loss of proteins through the skin

Surgery – tissue damage, weeping of protein into the surrounding spaces

Question 4

3 mechanisms of volume regulation

Answer 4

RAS

ADH

Sympathetics

Question 5

what are the components of BMP:

Answer 5

Na, K

Cl, HCO3

BUN, Cr

Glucose

Question 6

what are the normal values of the components of BMP:

Answer 6

Na – 135

K - 4

Cl - 100

Bicarb – 18 to 30

BUN – 7 to 20

Cr – .7 to 1.3

Glucose < 125