Lecture 4 Flashcards
Nongenetic factors account for about __% of congenital hearing loss
25
✤ Nongenetic factors known to cause congenital HL include:
-rubella (German measles)
-cytomegalovirus
-herpes simplex virus
-Prematurity
-Low birth weight
• Birth injuries
• Toxins including drugs and alcohol consumed by the mother during pregnancy
-Maternal diabetes
-Toxemia during pregnancy (preclampsia)
• Lack of oxygen (anoxia)
Prematurity is defined as birth prior to __ weeks
Can be __% more likely than normal term infants to develop HL.
37
50%
- Preterm birth < __ weeks gestation.
2. very preterm birth __ weeks gestation
37
32
42
low Birth Weight (LBW) is
5.5
3lb 5 oz
2lb 3 oz
The Apgar Score is a standardized assessment of infants after delivery and has 5 components. what are they?
- heart rate
- respiratory effort
- muscle tone
- reflexirritability
- color
The Apgar Score:
✤ Score of 7-10 is ___
✤ Score of 4, 5, or 6 are _____
✤ Score of 0, 2, or 3 are _____
- Normal
- intermediate
- low
True or False?Any disorders of respiration may cause sensorineural hearing loss due to hypoxemia
true
_____ ______ are a group of congenitally acquired infections that cause significant morbidity and mortality in neonates
Acquired by the mother and passed either transplacentally or during the birth process
TORCH
TORCH: T = O= R= C= H=
Toxoplasmosis Other bacterial infections; syphilis Rubella Cytomegalovirus Herpes Symplex Virus
Toxoplasmosis:
- Causative organism?
- Transmission?
- symptoms?
- Treatment?
- Toxoplasma gondii
- Transplacental
-Fecal-oral route
-Cat feces
-Found in
undercooked meat,
contaminated water/
soil, and
unpasteurized goat
milk.
- Transplacental
- Adults typically are asymptomatic
- Neonates may be asymptotic at birth
- Visual problems
- Hearing loss -
- Neurodevelopmental delay - Pyrimethamine (malarial drug) Sulfadiazine (antibiotic)
Syphilis:
- Causative organism?
- transmission?
- symptoms?
- treatment?
- Treponema palladium
- transplacental and sexual activity
- Progressive SNHL
• Vestibular disorders
• Malformation of the
teeth and jaw
• Perforated hard palate - antibiotics for mother during pregnancy. penicillin for infant
Rubella:
- Causative organism?
- transmission?
- symptoms?
- treatment?
- Togavirus
- transplacental and respiratory secretions
- • Hearingloss
• Rash
• Cataracts/Retinopathy
• Bone disease
• Heartconditions
• Psychomotor development - supportive care
Cytomegalovirus:
- Causative organism?
- transmission?
- symptoms?
- treatment?
- herpesvirus 5
- -transplacental
-perinatal
-contact with bodily fluids
-transmission is possible through reactivation of latent virus - -Most are asymptomatic at birth
-Developmental delay
• Microcephaly
• Progressive SNHL (10-15%)
-Postnatal infections are generally asymptomatic. - Antivirals have shown some promise Supportive care
Herpes Simplex Virus
- Causative organism?
- transmission?
- symptoms?
- treatment?
- HSV 1 and 2
- perinatal or direct contact with affected areas
3.
Fatal in 50% of neonates
Lesions/rash
• Organ dysfunction
• CNS disease (seizures, etc)
•SNHL - Acylovir