Lecture 4-6 Flashcards
What is the restorative theory of sleep?
- rest, recuperation
- repair effects of daily wear & tear
- physiological processes restored
- growth hormone released from pituitary: increased cellular division & RNA synthesis
- REM: protein synthesis, increases after learning
- N3 taxed in learning
What is the memory consolidation & learning theory of sleep?
- consolidation & facilitation of long-term memory
- brain rehearses newly learned info in N3
- declarative/explicit memory = N3 needed
- nondeclarative/implicit memory = REM needed
What is declarative/explicit memory?
- conscious recall
- semantic (concepts, facts, landmarks) + episodic (experiences, events)
What is nondeclarative/implicit memory?
- unconscious recall
- procedures, how to’s, motor skills, habits (throwing a ball, learn to drive, recognise faces)
What is the adaptive, survival theory of sleep?
Sleep patterns due to:
- predator or prey
- when can see optimally
- caloric use:
- sleep = less calories, less food
- awake when food most available
- environment:
- prevent drowning, sinking, danger
- cerebral hemispheres “take turns”
- move to warmth/cold
- safe, preferred sleeping location
- integrated into annual cycles: hibernation, reproduction
What is the energy conservation theory of sleep?
small animals: high metabolic rate - sleep longer with shorter NREM-REM cycles
larger animals: slower metabolic rate - sleep less, longer NREM-REM cycles
What is sleep like in mammals, birds, reptiles, amphibians, fish & invertebrates?
- > 90 species of mammals studied
- closer to humans = more similarities
- all reptiles and birds exhibit N3 & REM but species dependent
What is a sleep feature in birds?
less REM than mammals, except predator birds
What is a sleep feature in owls, moles & opossums?
no eye movements
What is a sleep feature in dogs, wolves, rabbits & birds?
not complete REM paralysis, much eye movements
- phasic eye movement
What is a sleep feature in reptiles, tortoises & turtles?
high amplitude spikes during sleep
- is it sleep or cold blooded torpor (physical & mental inactivity)?
What is sleep like in sea dwelling or migratory animals?
- cannot “settle” to sleep, surface breathing, flying long distances
- bottlenose dolphins, porpoises, pigeons, mallard ducks
- asynchronous brain sleeping
- large sea mammals: hold breath and sleep for 30mins, wake to surface & return down
What is asynchronous brain sleeping?
- one cerebral hemisphere at at a time
- half-brain in N2-N3, while other awake with opp. eye open; one hour each side
What is sleep like in bears, caterpillars & frogs?
hibernation:
- extreme lowering of body temp, metabolic rate, respiration, with short periodic bouts of rise over several weeks
- no/little recordable EEG
hibernation complete:
- sleep for extended period with increase in N3
What is sleep like in fruit fly, marine snail, scorpions, cockroaches & jellyfish?
quiescence & activity
What is sleep like in infants?
- newborn brain immature to produce adult EEG wave patterns
- AS, QS, IS
- healthy newborn: 16-18hrs, >50% in AS
- late term or premature: >75-80% in AS
- enter AS right after falling asleep
- distribution of sleep-wake numerous in nychthemeron
- QS & AS alternate in 50min cycles, increasing in time till 5mths old
- AS = REM at 3mths; QS = N3 at 6mths
What is active sleep (AS)?
low-voltage, irregular EEG, eye movements, low-high EMG, no motor paralysis; first smile
What is quiet sleep (QS)?
EEG similar to adult N3, no eye movement, mid-lower EMG, absence of body movements
What is intermediate sleep (IS)?
mixture of quiet and active
What is a nychthemeron?
period of 24 consecutive hours
What is sleep like in early childhood?
- 2-3mths: able to sleep thru night, w/ daytime naps
- 3mths: 40-50% in REM
- 5mths: at least 50% of infants sleep when parents sleep
- 8mths: 33% in REM, sleep 13-14hrs
- between 1-2 years: REM stabilizes at 25%, same as young adult
- 3-5 yrs: sleep 10-13 hrs & daytime napping ceases
What is the theory for early childhood sleep?
REM important to neural/nervous system maturation; needs stimulation
What is sleep like in children?
- NREM-REM cycle: 60mins
- enter N3 quickly, stay for 1hr, then arousal-sleep EEG, skip first REM
- position changes
- first REM 10-20mins, w/ subsequent periods 20-25mins
- by 10yrs: cycles resemble adults, but sleep 10hrs
- pre-teen (12-13yrs): fall asleep quickly, v. deep N3, v. difficult to wake
What is sleep like in adolescence?
- need 9+hrs per nycthemeron
- obtain 6-8hrs (+ sleep in, weekends): signs of sleep debt & deprivation
- 25% in REM
- circadian phase delay to later sleep hours
- vs. school times & learning expectations
What is sleep like in adults?
- fatal familial insomnia, death in 12-18mths
- average 7hrs, standard deviation of 1 hr
- 2/3 of population: 6.5-8.5hrs
- 16% of pop. 8.5+hrs, 16% of pop. <6.5 hrs
- minority: sleep <5 hrs regularly & healthy
- growing concern: ppl sleeping less
What is fatal familial insomnia?
prolonged sleep deprivation, inherited/passed down thru genes
What is sleep like in older adults?
- sleepier in day, less impact of sleep debt/deprivation
- difficult sleep onset, sleep less at night & fragmented, but naps
- sleepy in evening, awake in morning
- 48-50yrs: 4-6 hrs, N3 decline
- 50-60yrs: N3 diminish, 5-10% of sleep
- 85-90yrs: N3 disappears
- Alzheimer’s
- REM: some decrease, but maintained into extreme old age
- more REM earlier in night, more N1 sleep
What is Alzheimer’s?
marked reduction in N3
- theory: deterioration/less growth requirements of brain cells, cognitive abilities
- study results: long term sleep debt could cause Alzheimer’s
What are the differences between sleep in women & men?
women:
- go to bed earlier, fall asleep sooner, sleep longer
- more awakenings & time awake in each cycle
- “aging-related sleep changes”: 10 yrs later, 2x sleep spindles, slower N3 decline
- older women: longer to fall asleep, poorer quality & nap more
What are factors that affect women’s sleep?
- menstrual cycle: natural cyclic progesterone increases sleepiness & speeds sleep onset, estrogen increases REM length
- oral contraceptives: increase melatonin levels & body temp, shift into REM quicker
- menstruation: bloating & pain interrupts sleep
What is sleep like during pregnancy?
- metabolic changes, discomfort
- 1st trimester: increased sleepiness, disturbed sleep, blood volume doubles
- 2nd trimester: “grace period”
- 3rd trimester: more & longer awakenings; N3 declines approaching absence
- following birth: recovery from delivery, irregular sleep schedule, breastfeeding, postpartum depression
- 6mths to 1yr to recover most aspects of sleep, sleep efficiency remains low & number of awakenings high into childhood
What is sleep like during menopause?
- production of progesterone & estrogen decline, cease
- 40-75% of women complain of sleep issues
- hot flashes: 1.5-5yrs typical = brief arousals, >100 awakenings
- insomnia & sleep-disordered breathing
- hormone replacement therapy: help w/ some symptoms/sleep time, increase sleep quality
- lasts few years
What is phase shifting?
phase advancing/delaying
- advancing: shift biological clock forward to earlier time
- delaying: shift biological clock back to later time
What are sleep hour preferences?
- Morning Type (MT)
- Evening Type (ET)
- Neither Type (NT)
- genetic disposition, developmental/established habits
- teens become ET, gradually NT, MT characteristics seen by middle age
- questionnaire (Horne and Ostberg): time of day you rise, prefer to rise, feel your best, had to sleep at different times
What are the characteristics of MT?
- fall asleep more easily, better moods
- wake more during sleep
- more women tend to be MTs than men
What are the characteristics of ET?
- feel more alert & perform better later in day/night
- irregular bedtime habits: higher propensity for insomnia
- experience less jet-lag
- tolerate shift work better
What is the biological clock - circadian rhythm?
- “clock-dependent alerting”
- clock genes: Period (per), Timeless (Tim), circadian locomotor output cycles kaput (CLOCK)
- variability influences differences in circadian rhythms
- thousands of genes expressed at once in most tissues & organs regulate cellular function
- vs. stimulation alerting: transitory, once removed will fall asleep
- one peak/strong alerting mid-morning & one mid-late afternoon
- biological clock ensures small sleep debt cannot overwhelm us
What is clock-dependent alerting?
physiological process that maintains & consolidates daytime wakefulness
What is hypocretin/orexin?
neuropeptide that regulates arousal, helps sustain alertness
- narcolepsy = orexin deficiency
What is sleep homeostasis?
- sleep time reduced, tendency to fall asleep when awake increases
- “extra” sleep obtained, tendency to fall asleep while awake decreases
- ability to stay awake influenced by interaction of clock-dependent alerting & homeostatic sleep drive
- best sleep: timing of biological clock & wake-sleep schedule in synchrony
What is sleep need?
“individual requirement of nightly amount of sleep that results in consistent optimal daytime alertness”
What is sleep tendency?
strength of inclination/impulse to fall asleep