Lecture 4

Question 1

What does drying accomplish, and what are common drying methods?

Answer 1

Drying removes liquid from materials via heat. Methods include tray, tunnel, rotary, and freeze-drying. Drying rate depends on factors like liquid content

Question 2

What is the difference between powders and granules?

Answer 2

Powders are solid particles smaller than 1 mm, while granules are powder agglomerates larger than 1 mm.

Question 3

What is powder flowability, and what factors affect it?

Answer 3

Powder flowability is the ease with which powder moves. It is influenced by particle size, moisture, and charges, with larger particles generally showing better flow.

Question 4

What is granulation, and why is it important?

Answer 4

Granulation enlarges particles through agglomeration, turning powders into free-flowing, dust-free granules suitable for compression.

Question 5

What is direct compression in tablet manufacturing?

Answer 5

Direct compression is the process of compressing a blend of only API and excipients It has fewer processing steps, higher stability, and faster dissolution but limited excipient options and possible tablet defects.

Question 6

What are the typical steps in tablet manufacturing?

Answer 6

Blending, granulation, milling, drying, compression, and coating.

Question 7

What are excipients, and what are their roles in formulations?

Answer 7

Excipients are inactive ingredients added to aid processing, protect the API, and enhance patient acceptability.

Question 8

What factors affect tablet properties?

Answer 8

Tablet properties are influenced by the amount of material, punch position, and compression force

Question 9

What is tablet coating, and what are its functions?

Answer 9

ablet coating involves applying a thin layer to mask taste, improve swallowability, protect the API, and control drug release.