Lecture 4 Flashcards
(Regulation of Na+ Excretion)
Decreases in GFR decrease?
Na+ Excretion
(Regulation of Na+ Excretion)
Increases in GFR increase?
Na+ Excretion
(Regulation of Na+ Excretion)
Changes in Filtration Pressure with decreased?
Blood Pressure
(Regulation of Na+ Excretion)
Filter more = ?
Excrete more
Renin-Angiotensin-Aldosterone System?
-Aldosterone secreted from Adrenal Gland
-Aldosterone primarily to increase Na+ absorption in kidney
Aldosterone increases?
Na+ Reabsorption
Opening probability is increased by?
Aldosterone and abundance of protein (regulated by aldosterone)
Aldosterone primarily increases?
Activity of sodium pump
Angiotensin II Increases?
Na+ Reabsorption
-Increases Aldosterone
-Decreases Kf (SA)
-Increases Proximal Reabsorption
-Increases Filtration Fraction (FF)
Angiotensin II constricts?
Both afferent and efferent arterioles but has more effect on efferent arteriole
(Natriuretic Peptides Family)
ANP?
-Atria
-Other tissues
(Natriuretic Peptides Family)
BNP?
-Brain
-Atria
-Ventricles
(Natriuretic Peptides Family)
CNP?
-CNS
-Vasculature
Atrial Natriuretic Peptide (Factor) ANP (ANF) decreases?
Na+ Reabsorption
ANP to cGMP can?
Inhibit Na+ absorption
Decreased Protein Osmotic Pressure increases?
Na+ Excretion (glomerulus)
Sympathetic Increase?
Na+ Reabsorption
-Arterioles
-JG Cells
-Kf (SA)
-Tubule
Sympathetics (NE or Epi) increase?
Active Na/K APTase and thus increase Na reabsorption. Angiotensin II has a similar effect but different receptor
Increase Blood Flow to Cortex results in?
Increased Na+ excretion
Juxtamedullary Nephron is?
Salt Sparing
(more efficient in Na+ absorption)
Cortical Nephron is?
Salt Wasting
Pressure natriuresis/diuresis is an increase of?
Na+/water excretion caused by an increase in arterial pressure in the absence of a change in renal blood flow and glomerular filtration rate
