Lecture 1 Flashcards
Total Body Water?
(Body Fluids)
-Varies from 50-70% of body weight
-Average person is about 42 kg or 42 L
(Percentage of Water in Tissues)
Skin?
-72% of water
-18% of body weight
-9.1 L of water
(Percentage of Water in Tissues)
Muscle?
-76% of water
-41.7% of body weight
-22.1 L of water
Tissues that make up most of body H2O?
Skin and Muscle
Which Tissue is susceptible to edema?
Brain
Which Tissue is the least because of hydrophobicity?
Adipose Tissue
Intracellular (ICF)?
-40% of body weight
-28 L
Extracellular (ECF)?
-20% of body weight
-14 L
Plasma?
-4-5% of body weight
-25% of ECF
Interstitial?
-75% of ECF
What makes up the ECF?
Interstitial + Plasma
2/3 of TBW?
ICF
1/3 of TBW?
ECF
What can pass through cell membrane?
Only water
What wall is very permeable?
Capillary Wall
ECF + ICF = ?
TBW
(Measuring the Size of Compartments)
TBW?
(Radio-Labeled H2O)
HTO and D2O
(Measuring the Size of Compartments)
ECF?
-Inulin (only in ECF)
-Radio-sodium
(Measuring the Size of Compartments)
Plasma?
-I-albumin
-Evans Blue
(Measuring the Size of Compartments)
Blood?
Cr-RBCs
(Measuring the Size of Compartments)
Interstitial?
-Indirect
-(ECF - Plasma)
(Measuring the Size of Compartments)
ICF?
-Indirect
-(TBW - ECF)
Standard Equation?
Compartment Volume = (Amount Injected) / (Final Concentration)
Molar Concentration?
(# of atoms or charge of ion) x (mmol/L)
Plasma Electrolyte Total?
300 mOsmoles/L of H2O
Osmolality?
millimoles of solute/kg of H2O
Osmolarity?
millimoles of solute/L of H2O
Activity of H2O decreases as?
Osmolality increases
Colligative Properties of Solutions depend on?
Number of molecules and not their nature
-Boiling Point
-Freezing Point
-Vapor Pressure
-Osmotic Pressure
Decrease due to lots of protons (because HCl)?
Vomiting
Decrease due to lots of bicarb?
Diarrhea
(Daily Turnover of Fluids)
Infant?
-2.3 L of TBW (77%)
-16 (1/6)
(Daily Turnover of Fluids)
Adult?
-42 L of TBW (60%)
-6 (1/16)
Na primarily in?
Areas after the stomach
Cl primarily in?
Saliva and Gastric Juices
ECF cation is?
Na
ECF anion is?
Cl- (and HCO3-)
ICF cation is?
K+
ICF buffer is?
H2PO4-