Lecture 34: Menstrual Cycle and Ovulation (Part 2) Flashcards

1
Q

During days 1-10, describe the effects of FSH?

A

FSH stimulates follicular growth

-produces estrogen that inhibits LH

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2
Q

During days 10-14, describe the effects of estrogen?

A

Estrogen stops inhibiting LH and instead promotes LH production

  • triggers ovulation
  • promotes endometrium to undergo rapid growth
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3
Q

What two hormones are required for estrogen production?

A

FSH and LH

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4
Q

After ovulation, LH acts on the cells of what strcutre?

A

corpus luteum

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5
Q

What produces inhibin?

A

Granulosa cells of follicle

-stimulated by both FSH and LH

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6
Q

What do inhibins do?

A

Inhibit FSH production

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7
Q

What do activins do?

A

Promote FSH production

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8
Q

What part of the menstrual cycle utilizes positive feedback?

A

Days 10;14: Estrogen creates LH surge

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9
Q

What inhibits FSH and LH in the luteal phase?

A

Estradiol
Progesterone
Inhibin

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10
Q

When do levels of estradiol, progesterone, and inhibin decrease?

A

End of luteal phase

-promotes GnRH to release FSH and LH

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11
Q

During the follicular phase, what is the major product of the follicle?

A

Estradiol

-needs both theca and granulosa cells

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12
Q

During the follicular phase, what is the major product of the corpus luteum?

A

Progesterone

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13
Q

During the menstrual cycle, where can a rise in temperature be found?

A

Day after ovulation

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14
Q

What defines the menstrual phase of the menstrual cycle?

A

Day 1-5

-shedding of endometrium tissue resulting in menstrual bleeding

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15
Q

What defines the proliferative phase of the menstrual cycle?

A

Day 5-14

  • Proliferation of basal stromal cells and epithelial cells
  • components of endometrium
  • high levels of estrogen
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16
Q

What defines the secretory phase of the menstrual cycle?

A

Day 14-28

  • basculatrization of endometrium
  • progesterone production: differentiation of stromal cells into predecidual cells
17
Q

What is PCOS?

A

Polycystic Ovarian Syndrome

  • abnormal ovarian steroidogenesis: elevated LH and low FSH + elevated testosterone
  • increased androgen levels (DHEA)
18
Q

What are symptoms of PCOS?

A
  • Obese
  • Hirsutism
  • Infertility
  • Oligomenorrhea
19
Q

What is Turner Syndrome?

A

45, XO

  • absence of second chromosome
  • primary hypogonadism: germ cells don’t develop
  • elevated FSH levels
20
Q

What are symptoms of Turner Syndrome?

A
  • Short stature
  • Delayed puberty
  • Infertility
  • Webbed neck
  • Learning disabilities
21
Q

What marks menopause?

A

No menstrual period for 12 months

-low levels of inhibin –> high levels of LH and FSH

22
Q

What are symptoms of menopause?

A
  • Irregular periods
  • Vaginal dryness
  • Hot flashes
  • Night sweats
  • Mood changes
  • Sleep problems
  • Weight gain and slowed metabolism