Lecture 3 - Antigen recognition by MHC molecules (T cells) Flashcards
which 3 gene segments are t cell receptors encoded by? (similar to B cells)
V,D, J
when do gene segments of t cell receptors rearrange? in which location?
during development in the thymus
on which chromosome is the human MHC gene found?
6
on which chromosome is the TCR alpha gene found on?
14
on which chromosome is the TCR beta gene found on?
7
what does the polymorphism of MHC molecules lead to increased risk of?
what is this risk increased by ?
autoimmune disease
self presenting antigens
what is a downside regarding organ donors to MHC molecules being polymorphic?
reduced pool of organ donors available
MHC class 1 present peptides from antigens synthesised…….. in the…….
endogenously
in the cytoplasm
in MHC class 1, peptides are transported to the ER by a ……. transporter, containing……. and ……….
TAP
tapasin
calrecticulin
what is the second accessory molecule used in MHC I molecules? TAP and….
LMP
in MHC class 2, peptides are derived from antigens synthesised……
exogenously
in MHC II molecules, the antigen is endocytosed into what?
intracellular vesicles
both the peptide-MHC I and the peptide-MHC II complexes are presented on the surface of the cell, true or false?
true, they are both presented on the cell’s surface
what is the accessory molecule used by MHC II molecules to help load the peptide into the binding groove?
HLA-DM
MHC class II molecules bind to an invariant ER chain, involving which protein?
CLIP protein
