Lecture 3 Flashcards
Afterload
Load heart must eject blood against
Aortic pressure
Preload
Amount ventricles are stretched in diastole
Associated with EDV
Related to central venous pressure
Total peripheral resistance
Resistance to blood flow by all systemic vasculature
Main resistance vessels = arterioles
Effect on pressure with increased resistance
Decreases
Arterioles constrict - increase resistance and decrease pressure in capillaries
TPR increase
CO same
MABP increases
Venous pressure decreases
CO Increases
TPR same
MABP increases
Venous pressure decreases
Exercise
Arterioles and precapillary sphincters dilate- Vasodilation
TPR decreases
CO increases
MABP same
Stroke volume
EDV - ESV
70ml
Decreased compliance
Higher pressure at EDV
less stretch of walls
Hypertrophic and stiff
Common in elderly
Intrinsic control of BP
Frank Starking law
Increased venous return Increased venous pressure Increased EDV Increased stretch (pre load) Increased force of contraction Increased SV
Length tension
Too short - sarcomeres overlap - interfere with contraction
Max - 2.2 macrometres
Contractility
Force of contraction for a given fibre length for a giver EDP
Factors affecting contractility
Extrinsic factors
Sympathetic stimulation - adrenaline increase contractility
Aortic impedance
Aortic pressure
Factors affecting ESV and CO
EDV - Intrinsic factors Contractility - extrinsic factors Aortic impedance HR SV