lecture 3 Flashcards
NaCl in normal saline
0.9%
RMP is what and determined by…
electrical potential that exists across cell membrane
Due to concentrations and permeability of ions
How is RMP formed
when conc gradient and electrical gradient are balanced
RMP is important for excitable tissues otherwise
cardiac arrhythmias and muscle weakness
4 homeostatic terminology
regulated variable (system senses and keeps stable) set point (target value) reference normal range (acceptable limits) variation (intra and inter)
normal reference range is
2sdv away from mean in healthy group of ppl
variation fluctuates due to
inter/intra variation= genetic/fluctuate rhythms
negative feedback components
sensor
integrator
effector
communication pathways
neuronal pathway (4)
involves action potentials/neurotransmitter
fast
specific
for immediate brief change responses
hormonal pathway (4)
release into the blood
long lasting slow widespread sustained
target any cells with receptors specific
one hormone potentially affects many tissue/organs
feedforward
preemptive detection anticipation
before variable has moved
positive feedback detriments
destabilising, vicious cycles
positive feedback uses
childbirth, blood clotting, endpoint must limit outcome
mechanisms of heat loss
conduction, convection, radiation, evaporation