Lecture 3

Question 1

Three parts to ectoparasite control

Answer 1

1. Kill adults on pet with parasiticides
2. Prevent life cycle progression on the pet with IGRs
3. Control for adults and babies in the environment

Question 2

What do parasiticides target

Answer 2

Axon (Na, GABA, glutamate, Cl)

Synapse (Ca, acetylcholine, acetycholinesterase)

Question 3

Which parasiticides attack the axon

Answer 3

Pyrethrins/pyrethroids

Metaflumizone/indoxacarb

Macrocyclic lactones

Fipronil

Question 4

Which parasiticides attack the synapse

Answer 4

Organophosphates/ carbamates

Spinosad/ spinoteram

Imidacloprid/ nitepyran/ dinotefuran

Amitraz

Question 5

What does pyrethrins do

Answer 5

Increase Na permeability on axon

Question 6

Good and bad of pyrethrins?

Answer 6

Good- safe for cats and puppies

Bad- UV inactivated, short acting

Question 7

What do pyrethroids do

Answer 7

Increase Na on axon

Question 8

Good and bad of pyrethroids

Answer 8

Good- binds well, photostable, lasts longer than pyrethrin, repels if greater than 2%

Bad- toxic to cats!! (Greater than 0.5% is bad)

Question 9

Which vet products have permethrin

Answer 9

Advantix II

Actvivyl plus (plus indoxacarb)

Vectra 3D

Question 10

What is detamethrin

Answer 10

Pyrethroid

Collar

Can cause local irritation

Question 11

What does indoxacarb do

Answer 11

Blocks Na at axons

Uses metabolic bioactivation in the flea

Question 12

What does fipronil do

Answer 12

Inhibits GABA

Question 13

What product contains fipronil?

Good and bad about it?

Answer 13

Frontline

Good- IGR and adulticide, safe in cats

Bad- does not repel

Question 14

What is effitix

Answer 14

Has fipronil and permethrin

Question 15

What is tritak

Answer 15

Dogs- has fipronil, cypehnothrin, and methoprene

Cats- fipronil, etofenprox, and methoprene

Question 16

What is bravecto

Answer 16

Fluralaner
Inhibits arthropod GABA
Effective for demodex
Also topical

Question 17

What is nexgard

Answer 17

Afoxolaner
Same as fluralaner
Dogs only

Question 18

What is simparica

Answer 18

Sarolaner

More effective towards the end of the month than nexgard

Question 19

What parasiticides are no longer recommended due to there toxic effects

Answer 19

Organophosphates and carbamates

Question 20

What does spinosad do

Answer 20

Activates nACh receptors

Question 21

What products contain spinosad

Answer 21

Comfortis, trifexis

Question 22

Who should spinosad be avoided in

Answer 22

Dogs receiving ivermectin because it lowers threshold for seizures

Question 23

What does spinoteram do

Answer 23

Alters function of nicotinic and GABA channels

Question 24

What does imidacloprid do

Answer 24

Binds and stimulates nACh receptors

Question 25

Which products contain imidacloprid

Answer 25

Advantage II and multi Advantix II Seresto

Question 26

Which products contain nitenpyram

Answer 26

Capstar Bad because only lasts 24 hrs

Question 27

What contains dinotefuran

Answer 27

Vectra 3D Has IGR, adulticide and repellant in one product! Has permethrin so toxic to kitties

Question 28

What are IGRs

Answer 28

Methoprene Pyriproxifen Lufenuron

Question 29

How methoprene work

Answer 29

Mimics JH-1 which prevents molting

Question 30

Which products have methoprene

Answer 30

Precor | Frontline plus

Question 31

Which products have pyriproxifen

Answer 31

Nylar, vectra 3D

Question 32

How does luferuron work

Answer 32

Inhibits chitin synthesis

Question 33

What is bad about luferuron

Answer 33

There is a 3 month lag phase if this product is used alone

Question 34

How do macrocyclic lactones work

Answer 34

Increase GABA and glutamate

Question 35

What products have macrocyclic lactones

Answer 35

Sentinel and novartis have milbemycin Ivermectin and heart guard Revolution has selamectin Advantage multi has moxidectin

Question 36

What does amitraz do

Answer 36

MOAI **toxic in horses and cats

Question 37

What product has amitraz and fipronil

Answer 37

Certifect

Question 38

Options for non chemical approach

Answer 38

Diatomaceous earth Beneficial nematodes Sodium polyborate

Question 39

General rules for environmental flea control

Answer 39

Focus on dark, moist areas Repeat every 3 weeks at the peak of season Combine adulticide and IGR

Question 40

Products with large amounts of permethrin

Answer 40

Advantix II Effitix Actvivyl Vectra 3D

Question 41

Products safe for cats

Answer 41

``` Advantage Frontline for cats Fipronil Activyl Vectra for cats Revolution ```