Lecture 3 Flashcards
(28 cards)
What is neonatal isoerythrolysis?
Mare makes antibodies to the foal’s RBCs and those antibodies are ingested with the colostrum.
The mare’s antibodies attach the foal’s RBCs and cause extravascular and intravascular hemolysis. What type of hypersensitivity is this?
Type II hypersensitivity
Donkeys have a specific ____ ____ present on their RBCs that is not expressed in horses.
Donkey factor
With neonatal isoerythrolysis, the onset of clinical signs ranges between ___ and ___ hours.
8 and 96 hours
What are 4 clinical signs of neonatal isoerythrolysis?
- Weakness
- Lethargy
- Icterus
- Hemoglobinuria
What 2 clinicopathologic abnormalities would you expect with neonatal isoerythrolysis?
- Anemia
2. Increased bilirubin
What is the equation used to determine the liters of blood used in a blood transfusion to treat neonatal isoerythrolysis?
[PCV(desired) - PCV(patient)] / PCV(donor) x BW x 0.08
What is major cross-matching?
Recipient plasma is tested against donor RBCs
What is minor cross-matching?
Recipient RBCs are tested against donor plasma.
For which antibodies should the mare be tested late in gestation?
- Aa
- Qa
- Ca
What is the Jaundice Foal Agglutination Test?
A stall-side test to determine if the mare’s colostrum reacts with the foal’s RBCs.
What type of cross-matching is the Jaundice Foal Agglutination Test?
Minor cross-matching
With a ventral septal defect, where would you hear the heart murmur?
Right side
What is choanal atresia?
No communication between the nasal cavity and pharynx
What are 2 clinical signs associated with choanal atresia?
- Respiratory distress
2. Open-mouth breathing
With lethal white foal syndrome, when would a foal typically start showing signs of colic?
24-36 hours after birth
What is lethal white foal syndrome?
An aganglionosis characterized by lack of submucosal and myenteric ganglia in the distal small intestine and large intestine.
Lethal white foal syndrome is associated with a mutation in what gene?
Endothelin B receptor gene
True or False: Guttural pouch tympany is painful.
FALSE
Severe swelling associated with guttural pouch tympany typically does not affect the health of a foal; however, ____, ____, and ____ have been documented.
- Dyspnea
- Dysphagia
- Aspiration pneumonia
How would one treat guttural pouch tympany?
Surgical correction - create a fenestration of the median septum to allow air to flow to the normal side.
Severe combined immunodeficiency disease is a(n) ____ ____ trait affecting ____ horses.
Severe combined immunodeficiency disease is an AUTOSOMAL RECESSIVE trait affecting ARABIAN horses.
Arabian foals affected by SCID are unable to produce which type(s) of cells?
- T lymphocytes
2. B lymphocytes
True or False: Foals with SCID appear normal at birth.
TRUE