Lecture 26- Intro to Tumor Biology Flashcards
1
Q
Differentiation is?
A
when cells become different to one another.
Embryo:
Early cells similar. Then they differentiate into 3 germ layers. Then cells further differentiate within these layers.
Post Embryonic:
Occurs at level of cells.
Maturation of differentiated cells from proliferative cells.
Involves
- inactivation o proliferative genes
- activation of special function genes
2
Q
De-differentiation is?
A
When things go wrong.
Reversion to primitive, embryonic proliferative cells.
3
Q
Disorders of growth
A
Embryo = malformations
-these occur in utero, eg) collection of abnormal blood vessels
Post-natal = abnormalities of
tissue function and tissue mass
Clinical Implications:
-Not all are disorders
