Lecture 25: Virus Replication Flashcards
What is the first step in the typical viral life cycle?
Adsorption of virus to cell receptors
Adsorption of virus to cell receptors
What is the second step in the typical viral life cycle?
Penetration of virus into cell
What occurs during the eclipse period of virus replication?
Expression of viral genes, production of viral genome, production of viral proteins
What is the final step in the typical viral life cycle?
Assembly of viral particles & release from cell
What is the significance of cell surface receptors in viral adsorption?
Every virus has its own cell surface receptor
Which receptor does HIV bind to on T-helper cells?
CD4
Which receptor does the rabies virus bind to on neurons?
Acetylcholine receptor
Which receptor does HSV bind to?
Fibroblast growth factor receptor
What is the process of penetration and uncoating in virus replication?
The virus enters the cell and sheds its protective coat
What are the types of viral genomes that influence reproduction?
- DNA viruses
- Retroviruses
- Positive RNA
- Negative RNA
What is involved in the maturation of virus particles?
Self-assemble: genome associates with capsid proteins to form capsid
How are naked virions released from cells?
Cell lysis
How are enveloped virions released from cells?
Budding
