Lecture 24 Flashcards

1
Q

Intestinal epithelial cells: replaced every –

A

few days

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2
Q

Skin cells: replaced every –

A

2-4 weeks

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3
Q

Hepatocytes, heart muscle cells, neurons: replaced only during –

A

healing processes

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4
Q

Cancer occurs when the mechanisms that maintain these normal growth rates malfunction to cause –

A

excess cell division

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5
Q

A cell with impaired abilities to control its proliferation and tissue characteristics.

A

transformed cell

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6
Q

CANCER IS A – DISEASE

A

GENETIC

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7
Q

Cancer results from multiple genetic changes in a –

A

single cell

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8
Q

Cancer = Accumulation of mutations over lifetime:

A

late life disease

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9
Q

proto-oncogenes → oncogenes (gain-of-function)

A

promote cell growth

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10
Q

tumor suppressor→loss of function

A

restrain cell growth

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11
Q

care-taker genes→loss of function

A

protect genome integrity (repair)

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12
Q

Encode proteins that stabilize the genome

Tumors arise from both increase in point mutations and chromosome instability

A

care taker genes

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13
Q

Tumor cells frequently show – (i.e. highly aberrant chromosome compliments).

A

aneuploidy

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14
Q

Something in M phase cytoplasm causing G1 nuclei to enter mitosis. (induces mitosis)

A

Maturation Promoting Factor (MPF)

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15
Q

MPF is a –

A

Cdk and a cyclin.

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16
Q

Cells divide when cycling band decays. Cycling band called a –

A

cyclin.

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17
Q

T/F: The Cdk is only active when it is bound to cyclin.

A

true

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18
Q

The – of cyclin goes up and down with the cell cycle, therefore the kinase activity of Cdk also goes up and down with the cell cycle.

A

concentration

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19
Q

Cdc2 kinase is a –. In yeast there are two cyclins, a G1 cyclin and a mitotic cyclin.

A

Cdk

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20
Q

In yeast, a – in mitotic cyclin required to enter G1.

21
Q

Retinoblastoma encodes a protein that inhibits –, required for activation of DNA synthesis machinery

A

transcription factor E2F

22
Q

Rb is a – of Cdk

23
Q

Cyclins and CDKs are –

A

proto-oncogenes

24
Q

Mutation of cyclins can lead to – expression of cyclins, resulting in kinases that are always active

25
Other mutations can lead to CDKs that are active --
without cyclin
26
Mutations of -- can stimulate constant DNA synthesis and mitosis
proto-oncogenes
27
Growth factors are -- that stimulate cells to divide
mitogens
28
RAS is a G-protein that kinase cascade so RAS is a --
proto-oncogene
29
All cancer cells acquire same six characteristics | Ability to proliferate without --
external signal
30
All cancer cells acquire same six characteristics | Fail to sense signals that -- cell division
restrict
31
All cancer cells acquire same six characteristics | -- replicative potential
limitless
32
All cancer cells acquire same six characteristics | change their - to other cells
attachment
33
All cancer cells acquire same six characteristics | obtain a -- as they grow larger
blood supply
34
All cancer cells acquire same six characteristics | tissue invasion and --
metastasis
35
T/F: there are various pathways to cancer
true
36
Some cancers are inherited Heterozygous for mutant allele Good allele is --, leading down the road to cancer
lost
37
familial retinoblastoma -- eye tumors
many
38
sporadic retinoblastoma -- eye tumors
one
39
loss of heterozygosity through -- and --
nondisjunction and mitotic recombination
40
Effectors that can Inhibit Cell Cycle Machinery | -- (induces DNA damage in a cell)
Ionizing irradiation
41
Inhibits the kinase activity of the G1 cdk and prevents cells from entering into S.
p21
42
mutations can be found in 50% of human cancers.
p53
43
X-ray damages DNA → P53 is stabilized when DNA is damaged by phosphorylation = active p53 -->
production of p21
44
Retinoblastoma is a -- gene
tumor-suppressor
45
pass if cell size is adequate and chromosome replication is successfully completed
G2 checkpoint
46
pass if all chromosomes are attached to mitotic spindle
metaphase checkpoint
47
pass if cell size is adequate, nutrient availability is sufficient, and growth factors (signals from other cells) are present
G1 checkpoint
48
pass if DNA replication is complete and has been screened to remove base-pair mismatch or error
S-phase checkpoint