Lecture 21 - The genetics of intelligence

Question 1

(lecture):

How do we know that genes influence intelligence?

Answer 1

(lecture):

Twin studies

See slide 2

Question 2

(lecture):

Read slide 3-5

Answer 2

(lecture):

Question 3

(lecture):

Give some examples where low IQ is a characteristic of many rare neurogenic conditions.

Answer 3

(lecture):

See slide 6

Question 4

(lecture):

Read slide 7

Answer 4

(lecture):

Question 5

(lecture):

Read slide 8

Answer 5

(lecture):

Question 6

(lecture):

Give an example where genes interact with the environment.

Answer 6

(lecture):

See slide 9

Question 7

(lecture):

Within the general population, how do we identify genetic variants influencing intelligence?

Answer 7

(lecture):

See slide 10-11

Question 8

(lecture):

Read slide 12-14

Answer 8

(lecture):

Question 9

(lecture):

Should genetic data be interpreted in the context of environmental/societal information?

Answer 9

(lecture):

Yes

See slide 15

Question 10

(lecture):

Why would predicting an individual’s intelligence potentially be beneficial?

Answer 10

(lecture):

See slide 16

Question 11

(lecture):

How would you calculate an individual’s Polygenic Score (PS)?

Answer 11

(lecture):

See slide 17

Question 12

(lecture):

Is Polygenic Score (PS) a good predictor of an individual’s intelligence?

Answer 12

(lecture):

PS currently fairly poor predictor of an individual’s intelligence.

See slide 18

Question 13

(lecture):

How do we test links between intelligence and mental health conditions?

Answer 13

(lecture):

See slide 19-20

Question 14

(lecture):

Read slide 22

Answer 14

(lecture):

Question 15

(reading):

Deary IJ. (2013) Intelligence. Curr Biol. 23(16):R673-6

Hill WD et al. (2018) What genome-wide association studies reveal about the association between intelligence and mental health Curr Opin Psychol. 27:25-30

Answer 15

(reading):