Lecture 17 - The genetics of psychiatric and neurological disorders

Question 1

(lecture):

Some factors about DNA… (turn card)

Answer 1

(lecture):

DNA is very easy to get a hold of and it is very stable, (the DNA you are born with is the DNA you die with)

see slide 3

Question 2

(lecture):

Describe an early approach to identifying genetic risk variants.

Answer 2

(lecture):

See slide 4-5

Question 3

(lecture):

Describe linkage studies.

What are some limitations of these?

Answer 3

(lecture):

See slide 6-10

Question 4

(lecture):

Describe candidate gene association studies.

What are some limitations of these?

Answer 4

(lecture):

See slide 11-13

Question 5

(lecture):

Describe Genome-wide association studies.

What are some limitations of these?

Answer 5

(lecture):

See slide 14-20

Question 6

(lecture):

Describe Copy Number Variant (CNV) studies.

What are some limitations of these?

Answer 6

(lecture):

See slide 21-22

Question 7

(lecture):

Describe exome and whole-genome sequencing.

What are some limitations of this?

Answer 7

(lecture):

See slide 24

Question 8

(lecture):

Describe Whole genome sequencing.

What are some limitations of this?

Answer 8

(lecture):

See slide 25

Question 9

(lecture):

Read slide 26-27

Answer 9

(lecture):

Question 10

(reading):

Current Opinion in Behavioral Sciences Volume 2 (April 2015) ‘Behavioral Genetics’

‘Genetics of schizophrenia’ Rees et al p8-14

‘Biological pathways and networks implicated in psychiatric disorders’ Sullivan and Posthuma p58-68

‘Psychiatric genomics: outlook for 2015 and challenges for 2020’ Crowley and Sakamoto p102-107

Answer 10

(reading):