Lecture 20-Hormones

Question 1

How many C’s do androgens have?

Answer 1

19

Question 2

pregnane

Answer 2

21 Cs

Question 3

androstane

Answer 3

19 Cs

Question 4

estrane

Answer 4

18 Cs

Question 5

cyclopentanoperhydrophenanthrene

Answer 5

17-C nucleus of all steroids

Question 6

Isocaproaldehyde

Answer 6

a 6 C biproduct of P450SCC conversion of cholesterol to pregnanolone in mitochondria

Question 7

glucocorticoids have ____ Cs

Answer 7

21

Question 8

lysosteroid

Answer 8

Vit D is an example–it looks like a steroid but is not becaues it does not form a 3-6ring structure

Question 9

What are 4 examples of glycoproteins?

Answer 9

TSH, LH, FSH, CG

Question 10

Describe where glycoproteins are found and a little about their function. (what they activate, structure)

Answer 10

• Placental and pituitary hormones
• activate cAMP pathways
• all have the same alpha subunit with different beta subunits

Remember, glycoproteins are : TSH, LH, FSH, CG

Question 11

Give an example of a paracrine function for each of the following classes of hormones:

• steroid
• protein
• AA derivatives
• Eicosanoids

Answer 11

• testosterone acting on Leydig cells to promote spermatogenesis
• insulin from beta cells acting on alpha cells
• histamine acting locally on blood vessels; NTs/neuromodulators
• prostaglandin released for inflammation

Question 12

Give examples of an autocrine function of each of the following:

• proteins/peptides
• eicosanoids

Answer 12

• growth hormone
• thromboxane acting on platelets

Question 13

how are proteins/aa derivatives stored? How are they transported.

Answer 13

They are stored in secretory vesicles,

transported without binding protein