Fat hormones

Question 1

leptin

Answer 1

• signal to brain about fat stores.
• can increase lypolysis and uncoupling protein to burn fat stores
• signals through SNS

Question 2

visfatin

Answer 2

• binds insulin receptor and enhances glucose uptake

Question 3

adiponectin

Answer 3

• synergistic with insulin and visfatin to enhance glu uptake
• Activates AMPK
• FA oxidation in muscle increase

Question 4

Resistin

Answer 4

• in macrophages and adipocytes
• induces insulin resistance
• low during fasting, high in obesity

Question 5

Lipin

Answer 5

• in nucleus of adipocytes and skeletal muscle
• deficiency causes lipodystrophy
• excess = obesity

Question 6

TNF-alpha

Answer 6

• pro inflammatory cytokine
• interferes with insulin receptor signaling
• possible cause of insulin resistance in obesity

Question 7

IL-6

Answer 7

induces insulin resistance

Question 8

Angiotensinogen

Answer 8

• regulator of blood pressure

- electrolyte homeostasis

Question 9

adipsin

Answer 9

• protease identical to complement D

- down regulated in obesity

Question 10

ASP

Answer 10

• Acetylation stimulating protein
• increases after fatty meal
• stimulates TG synthesis

Question 11

FIAF

Answer 11

• fasting induced adipose factor

- may be reciprocal to leptin

Question 12

AdipoQ

Answer 12

• may play a role in pathogenesis of Familial Combined Hyperlipidemia
• associated with insulin resistance

Question 13

PGI2/PGF2alpha

Answer 13

• implicated in regulatory functions such as inflammation, blood clotting, ovulation, menstruation, acid secretion

Question 14

TGF beta

Answer 14

• increases pre-adipocyte proliferation

Question 15

PAI-1

Answer 15

• Plasminogen activator inhibitor-1

- link between obesity and CHD