Lecture 20 And 21 - The Enery Distribution System Flashcards

1
Q

The Energy Distribution System

A

Energy is defined as the capacity to do work

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2
Q

ATP - Adenosine Triphosphate

A

The medium of energy exchange - energy currency of the cell

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3
Q

Reducing Equivalents

A

Glycolysis, beta oxidation and Kreb’s Cylce produce NADH and FADH2 (supply protons and electrons to the ETC)

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4
Q

Anaerobic ATP Production

A
  • Phosphocreatine degradation
  • Glycolysis (end product is lactate in anaerobic conditions)
  • inefficient but fast
  • ATP is rebuild by adding a phosphate to ADP
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5
Q

Fat

A

most energy is stored as triglycerides in our adipocytes (fat cells in adipose tissue)

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6
Q

Carbohydrate Stored as:

A
  • Liver: Glycogen (overnight)
  • Muscle: Glycogen (during exercise)
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7
Q

Protein

A
  • large potential energy source
  • used during starvation or caloric restriction
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8
Q

Pro of Carbohydrates

A
  • Aerobically can generate ATP slightly faster than from fat
  • Can also generate ATP anaerobically (3x faster)
  • good for long exercise (storing glucose for later so skeletal muscle isn’t used)
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9
Q

Con of carbohydrate

A

Holds a lot of water

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10
Q

Pro of Fat

A
  • doesn’t hold water, twice as energy dense as carbohydrate
  • represents our most abundant energy reserve
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11
Q

Cons of Fat

A

Can’t provide energy anaerobically

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12
Q

Absorptive State

A
  • first 3-4 hours after a meal
  • energy (macronutrients) are stored (anabolism)
  • excess calories in the form of glucose or amino acids can get converted to fat
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13
Q

Post absorptive state

A
  • fasting
  • stored macronutrients are mobilized for energy (catabolism - break down of macronutrients)
  • glucose is spared for nervous system
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14
Q

Gluconeogenesis

A

Making glucose from non-carbohydrates precursors

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15
Q

Normal Fasting Blood Glucose

A

4 - 5.5 mM

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16
Q

Fasting Hyperglycaemia

A

glucose > 7mM

17
Q

Fasting Hypoglycaemia

A

glucose ~ 3.5mM

18
Q

How to challenge the energy distribution system

A

Exercise

19
Q

Cancer Cachexia

A
  • Cancer Cells Grown and Devide Rapidly forming a tumour
  • Tumours have high energy demands to support rapid cell devision (require large amounts of ATP)