Lecture 20

Question 1

iodide is transported across the apical membrane of the cell into follicle via a Cl iodide counter transporter called

Answer 1

pendrin

Question 2

iodine is combined with tyrosine or thyroglobulin, catalyzed by peroxidase and results in

Answer 2

MIT or DIT

Question 3

DIT and DIT is

Answer 3

T4, thyroxine

Question 4

MIT and DIT is

Answer 4

T3, triiodothyronine, more active

Question 5

thyroid cells also secrete __ into follicle

Answer 5

thyroglobulin

Question 6

each thyroglobulin contains about __ molecules of thyroxine

Answer 6

30

Question 7

apical surface of thyroid cells pinch off small portions fo the follicular colloid to form

Answer 7

pinocytic vesicles

Question 8

conversion of T4 to T3 requires

Answer 8

5’-iodinase

Question 9

most thyroid hormones entering the blood are bound to a plasma protein that was synthesized in the liver called

Answer 9

thyroxine binding globulin (TBG)

Question 10

two cases of hyperthyroidism are

Answer 10

graves’ disease and adenoma

Question 11

intolerance to heat, weight loss, diarrhea, muscle weakness and high state of excitability are all symptoms of what

Answer 11

hyperthyroidism

Question 12

how do you treat hyperthyroidism

Answer 12

removal of thyroid gland or treatment with radioactive iodine

Question 13

3 causes of hypothyroidism are

Answer 13

hashimoto disease, endemic goiter, cretinism

Question 14

this drug inhibits iodine uptake (inhibits I-/Na+ cotransport)

Answer 14

thiocyanate and perchlorate

Question 15

this drug inhibits peroxidase and can be used to treat hyperthyroidism

Answer 15

propylthiouracil

Question 16

this drug decreases thyroid activity when present in very high concentrations

Answer 16

iodides