Lecture 2- The Cancer Cell Cycle

Question 1

What are some experimental systems we can use to study cell cycle genes and proteins?

Answer 1

Slide 4

Question 2

Discuss the cell cycle of fission yeast. How was fission yeast studied to identify human cdc2?

Answer 2

Slide 6-10

Question 3

Discuss MPF and what it contains.

Answer 3

Slide 11-14

Question 4

How were cyclins identfied?

Answer 4

Slide 15

Question 5

What does the cdc2-cyclin B complex do?

Answer 5

Slide 16

Question 6

How is CDK activity regulated?

Answer 6

Slide 17

Question 7

What roles do other cyclins have in interpase?

Answer 7

Slide 18

Question 8

How does the yeast cell cycle differ from the mammalian cell cycle?

Answer 8

Slide 19-20

Question 9

Discuss the dispensability in the mammalian cell cycle.

Answer 9

Slide 21-22

Question 10

How do D-type cyclins integrate mitogenic signals?

Answer 10

Slide24

Question 11

What happens at the R point? How may the R point deregulated in cancers?

Answer 11

Slide 25-26

Question 12

How may D-type cyclins be involved in tumorigenesis?

Answer 12

Slide 27-28

Question 13

Discuss palbociclib as a treatment for breast cancer.

Answer 13

Slide 29-30

Question 14

How is cyclin B1 linked to breast cancer?

Answer 14

Slide 31-32

Question 15

How can CDKs be selectively inhibited?

Answer 15

Slide 33

Question 16

What role does CDK1 have in maintaining stem cell chromatin state

Answer 16

Slide 34