Lecture 2 part 3

Question 1

Volume of Distribution InterpretationA drug has a Vd = 15-18 L, what that implies?

Its distribution is limited to _________ in a 70 kg

Answer 1

ECF

Question 1

A drug has a Vd = 40 L, what that implies?

Drug distributing into all __________

Answer 1

body water

Question 2

If a drug has a Vd greater than 40-50 L, what
that implies?

Drug probably is being concentrated in tissues
outside the plasma and interstitial fluid or there is
protein/tissue binding