Lecture 2: Introduction to Ethnobotany Flashcards
Ethnobotany
Explores the fundamental relationships that exist between plants and indigenous/traditional cultures from around the world e.g. as medicines, foods, intoxicants, clothing, shelter, ship building material etc.
——- is a traditional Chinese medicine that is the source of the antimicrobial Artemisinn
Qinghao
Drug discovery pathway
1) Ethnobotanical information and Historic texts
2) Botanical identification
3) Preparation of extracts
4) Biological assays
5) Biological - guided fractionation
6) Active compound identification
7) Medicinal chemistry and structure-activity relationship
8) Toxicology, Pharmacology, ADME, PK/PD, Formulation
9) Clinical studies (Hit improvement - Lead improvement - Drug candidate - Preclinical - Clinical)
10) Drug
Hit vs. Lead
- A hit compound is a molecule that shows the desired type of activity in a screening assay.
- Lead compounds are selected from a collection of hits by refining the screening criteria to enable the selection of the most promising molecules for further development.
Seedless Vascular plants with examples
plants that produce spores
e.g. ferns, horsetails, clubmosses
Gymnosperms with examples
plants that produce cones
e.g. conifers, cypress, gingko
Angiosperms with divisions
plants that produce flowers
division: monocots and dicots
Structure of gymnosperms
- have a naked sperm
- almost all are woody
- almost all are evergreen
scientific name of ferns and types
Pterdophytes
- sori and fertile frond
Cycads: gymnosperm or angiosperm or seedless vascular
gymnosperm
gymnosperm or angiosperm or seedless vascular: Plum pines
gymnosperm
gymnosperm or angiosperm or seedless vascular: cypress
Gymnosperm
gymnosperm or angiosperm or seedless vascular: Ephedra
gymnosperm
gymnosperm or angiosperm or seedless vascular: fir
gymnosperm
gymnosperm or angiosperm or seedless vascular: spruce
gymnosperm
