Lecture 2- Drugs to treat Heart failure Flashcards
inotropic drugs alter the …. or … of muscular contractions
force
energy
positive inotropes increase the …
strength of muscular contraction (negative inotropes weaken it)
chronotropic drugs may change the …. by …
heart rate
affecting the nerves controlling the heart or by changing the rhythm produced by the SA node
positive chronotropes … HR, negative chronotropes … HR
increase
decrease
3 positive inotropic drugs to treat HF
- cardiac glycosides: digoxin
- b-adrenergic receptor agonists
- bipyridines
MOA of digoxin
blocks Na/K ATPase so internal Na increases, slowing removal of Ca (keeps calcium inside)
Digoxin …. ventricular ejection, CO, and renal perfusion
increases
dobutamine is the most popular….
beta agonist (positive inotrope)
Inamrinone and milrinone are …. which are … inhibitors resulting in more cAMP
bypridines
phosphodiesterase-3
digoxin MOA
blocks Na/K ATPase (slows removal of calcium)
most common drugs to treat angina pectoris
nitrates
calcium blockers
beta blockers
sildenafil (viagra) …. the action of nitrates
potentiates. so this combo is contraindicated for the severe hypotension that could occur
most adverse effect of nitrates
headache (can also cause hypotension, facial flushing and tachycardia)
