Lecture 2 - Common Skin Conditions Flashcards
What is atopic eczema/atopic dermatitis?
Inflammation of the skin causing it to be really dry, itchy, red and flaky
What parts of the body does atopic eczema usually present on?
Flexural surfaces (elbows, backs of knees)
What is eczema called when it occurs in response to a specific trigger?
Contact dermatitis
How is atopic eczema diagnosed?
A clinical diagnosis meaning it can be diagnosed by taking a Hx and an exam alone
What is a typical Hx for a patient with atopic eczema?
Family Hx
Atopy
Normally happens in childhood
How is atopic eczema treated?
Education and support
Avoid triggers like smoke ad fragrances causing flare ups
Topical changes:
Emollients
Soap substitutes
Steroids and or calcineurin inhibotrs
Phototherapy
Or systemic therapy
What is the function of steroids in treating atopic eczema?
Reduces inflammtion
What is the function of calcineurin inhibitors in atopic eczema?
Topical immunosuppressants
What is acne vulgaris?
Chronic skin disease where the hair follicles in the skin get blocked
Who does Acne vulgaris typically affect?
Adolescents to young adults
How is acne vulgaris diagnosed?
Clinical diagnosis (Hx and exam alone)
What are the ways that acne vulgaris is thought to be caused?
Increased sebum (oil) production due to androgen influence
Excessive deposition of keratin in pores (dead skin cells)
Overgrowth of cutibacterium acne’s (a skin commensals)
What is the microbe involved in acne vulgaris?
Cutibacterium acnes
What supports the growth of cutibacterium acne’s in acne vulgaris?
The oily environment caused by the excess sebum production
What is the treatment for acne vulgaris?
Topical treatments which can be antibiotic or non antibiotic
What are some non antibiotic treatments for acne vulgaris?
Retinoids
Benzoyl peroxide
What are some topical antibiotics for acne vulgaris?
Erythromycin
Clindamycin
What are some systemic treatments for acne vulgaris?
Abx
Oral contraception
Isotretinoin
Why is isotretinoin heavily regulated in its use for treatment of acne vulgaris?
Highly teratogenic (so try and avoid using in fertile woman and defo onto in pregnant women)
Also can cause depression, psychiatric disorder and suicidal tendencies
How does psoriasis present?
Chronic skin condition
Plaques
Silvery scales
Normally on the extensor surfaces (knees, elbows and scalp)
Relaxing and remitting course
May come after new medications
How is psoriasis diagnosed?
Clinical diagnosis
What is tthe cause of psoriasis?
T cell cytokine production is stimulated leading to keratinocytes proliferation (rapid maturation of skin cells)
What is the treatment for psoriasis?
Topical treatments
Phototherapy (exposure to UV)
Systemic drugs (oral and injectable)
What are the potential systemic treatments for psoriasis?
Methotrexate
Ciclosporin
What are the potential iatrogenic causes of psoriasis?
Beta blockers
ACE Inhbitors
What is urticaria?
Appears as hives
Associated with angiooedma
Looks kinda like me when i write on my skin
What triggers urticaria?
Foods
Inhaled allergens viral infection
What is the pathophysiology of urticaria?
Mast cells degranulation and histamine is released leading to increased capillary permeability and leakage of fluid into surrounding tissue
What is considered acute urticaria?
What is considered chronic urticaria?
Acute < 6weeks
Chronic >6weeks